7w5c
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of Mitogen Activated Protein Kinase 4 (MPK4) from Arabidopsis thaliana== | |
| - | + | <StructureSection load='7w5c' size='340' side='right'caption='[[7w5c]], [[Resolution|resolution]] 2.20Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[7w5c]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7W5C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7W5C FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ANP:PHOSPHOAMINOPHOSPHONIC+ACID-ADENYLATE+ESTER'>ANP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7w5c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7w5c OCA], [https://pdbe.org/7w5c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7w5c RCSB], [https://www.ebi.ac.uk/pdbsum/7w5c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7w5c ProSAT]</span></td></tr> |
| - | [[Category: | + | </table> |
| - | [[Category: | + | == Function == |
| + | [https://www.uniprot.org/uniprot/MPK4_ARATH MPK4_ARATH] The ANPs-MKK6-MPK4 module is involved in the regulation of plant cytokinesis during meiosis and mitosis. Essential to promote the progression of cytokinesis and for cellularization (formation of the cell plate) during male-specific meiosis. Involved in cortical microtubules organization and stabilization by regulating the phosphorylation state of microtubule-associated proteins such as MAP65-1. Involved in root hair development process. Negative regulator of systemic acquired resistance (SAR) and salicylic acid- (SA) mediated defense response. Required for jasmonic acid- (JA) mediated defense gene expression. May regulate activity of transcription factor controlling pathogenesis-related (PR) gene expression. Seems to act independently of the SAR regulatory protein NPR1 (Nonexpresser of PR1). Phosphorylates MKS1 and transcription factors WRKY25 and WRKY33. The MEKK1, MKK1/MKK2 and MPK4 function in a signaling pathway that modulates the expression of genes responding to biotic and abiotic stresses and also plays an important role in pathogen defense by negatively regulating innate immunity (PubMed:11163186, PubMed:15225555, PubMed:15358537, PubMed:15990873, PubMed:18982020, PubMed:20215588, PubMed:20802223, PubMed:21098735, PubMed:21575092, PubMed:25770109). Phosphorylates MEKK2 upon treatment with flg22 (PubMed:22643122). Involved in stomatal movement regulation by repressing HT1 and HT1-mediated GHR1 phosphorylation (PubMed:27694184, PubMed:27923039).<ref>PMID:11163186</ref> <ref>PMID:15225555</ref> <ref>PMID:15358537</ref> <ref>PMID:15990873</ref> <ref>PMID:18982020</ref> <ref>PMID:20215588</ref> <ref>PMID:20802223</ref> <ref>PMID:21098735</ref> <ref>PMID:21575092</ref> <ref>PMID:22643122</ref> <ref>PMID:25770109</ref> <ref>PMID:27694184</ref> <ref>PMID:27923039</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Arabidopsis thaliana]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Arold ST]] | ||
| + | [[Category: Hameed UFS]] | ||
Revision as of 08:14, 7 December 2022
Crystal structure of Mitogen Activated Protein Kinase 4 (MPK4) from Arabidopsis thaliana
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