7y4i
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of SPINDLY in complex with GDP== | |
| - | + | <StructureSection load='7y4i' size='340' side='right'caption='[[7y4i]], [[Resolution|resolution]] 2.85Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[7y4i]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7Y4I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7Y4I FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7y4i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7y4i OCA], [https://pdbe.org/7y4i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7y4i RCSB], [https://www.ebi.ac.uk/pdbsum/7y4i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7y4i ProSAT]</span></td></tr> |
| - | [[Category: | + | </table> |
| - | [[Category: Wan | + | == Function == |
| + | [https://www.uniprot.org/uniprot/SPY_ARATH SPY_ARATH] Probable O-linked N-acetylglucosamine transferase (OGT) involved in various processes such as gibberellin (GA) signaling pathway and circadian clock. OGTs catalyze the addition of nucleotide-activated sugars directly onto the polypeptide through O-glycosidic linkage with the hydroxyl of serine or threonine. Probably acts by adding O-linked sugars to yet unknown proteins. Acts as a repressor of GA signaling pathway to inhibit hypocotyl elongation. Functions with GIGANTEA (GI) in pathways controlling flowering, circadian cotyledon movements and hypocotyl elongation. Acts as a light-regulated promoter of elongation via its interaction with GI. Acts as an activator of cytokinin signaling. Required with SEC for gamete and seed development (PubMed:12136030). Its OGT activity has been proved in vitro but not in vivo (Ref.5, PubMed:11457967, PubMed:12136030, PubMed:15155885, PubMed:15608330, PubMed:8799194). Possesses O-fucosyltransferase activity on specific serine and threonine residues (PubMed:28244988). Mediates O-fucosylation of the DELLA protein RGA, a repressor of the GA signaling pathway (PubMed:28244988). O-fucosylation enhances RGA activity by promoting RGA binding to key transcription factors in brassinosteroid and light-signaling pathways (PubMed:28244988). Regulates root hair patterning upstream of the transcription factor WER, independently of DELLA proteins and GA signaling (PubMed:32928908). Involved in abscisic acid (ABA) signaling partly through functional ABAR (PubMed:34712252). Mediates O-fucosylation of CPN20 that may depress ABA responses during seed germination and seedling development (PubMed:34712252). Involved in the modulation of the pace of the circadian clock by mediating O-fucosylation of APRR5, one of the core circadian clock components (PubMed:31899321). O-fucosylation promotes APRR5 proteolysis (PubMed:31899321).<ref>PMID:11457967</ref> <ref>PMID:12136030</ref> <ref>PMID:15155885</ref> <ref>PMID:15608330</ref> <ref>PMID:28244988</ref> <ref>PMID:31899321</ref> <ref>PMID:32928908</ref> <ref>PMID:34712252</ref> <ref>PMID:8799194</ref> <ref>PMID:12136030</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Arabidopsis thaliana]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Wan LH]] | ||
| + | [[Category: Xu ST]] | ||
Revision as of 08:15, 7 December 2022
Crystal structure of SPINDLY in complex with GDP
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