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8avg
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Cryo-EM structure of mouse Elp123 with bound SAM== | |
| - | + | <StructureSection load='8avg' size='340' side='right'caption='[[8avg]], [[Resolution|resolution]] 4.01Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[8avg]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8AVG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8AVG FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SAM:S-ADENOSYLMETHIONINE'>SAM</scene>, <scene name='pdbligand=SF4:IRON/SULFUR+CLUSTER'>SF4</scene></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8avg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8avg OCA], [https://pdbe.org/8avg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8avg RCSB], [https://www.ebi.ac.uk/pdbsum/8avg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8avg ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/ELP1_MOUSE ELP1_MOUSE] Component of the elongator complex which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine) (By similarity). The elongator complex catalyzes the formation of carboxymethyluridine in the wobble base at position 34 in tRNAs (PubMed:23717213). Regulates the migration and branching of projection neurons in the developing cerebral cortex, through a process depending on alpha-tubulin acetylation (PubMed:22854966). ELP1 binds to tRNA, mediating interaction of the elongator complex with tRNA (By similarity). May act as a scaffold protein that assembles active IKK-MAP3K14 complexes (IKKA, IKKB and MAP3K14/NIK) (By similarity).[UniProtKB:O95163][UniProtKB:Q06706]<ref>PMID:22854966</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Mus musculus]] | ||
| + | [[Category: Abbassi N]] | ||
| + | [[Category: Biela A]] | ||
| + | [[Category: Chramiec-Glabik A]] | ||
| + | [[Category: Dobosz D]] | ||
| + | [[Category: Gaik M]] | ||
| + | [[Category: Glatt S]] | ||
| + | [[Category: Hammermeister A]] | ||
| + | [[Category: Indyka P]] | ||
| + | [[Category: Jaciuk M]] | ||
| + | [[Category: Kaszuba K]] | ||
| + | [[Category: Koscielniak A]] | ||
| + | [[Category: Kosinski J]] | ||
| + | [[Category: Krutyholowa R]] | ||
| + | [[Category: Lin T-Y]] | ||
| + | [[Category: Rawski M]] | ||
| + | [[Category: Schaffrath R]] | ||
| + | [[Category: Scherf D]] | ||
Current revision
Cryo-EM structure of mouse Elp123 with bound SAM
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Categories: Large Structures | Mus musculus | Abbassi N | Biela A | Chramiec-Glabik A | Dobosz D | Gaik M | Glatt S | Hammermeister A | Indyka P | Jaciuk M | Kaszuba K | Koscielniak A | Kosinski J | Krutyholowa R | Lin T-Y | Rawski M | Schaffrath R | Scherf D
