8bgm
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of the OrfX1-OrfX3 complex from the PMP1 neurotoxin gene cluster== | |
| + | <StructureSection load='8bgm' size='340' side='right'caption='[[8bgm]], [[Resolution|resolution]] 2.70Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[8bgm]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Paraclostridium_bifermentans Paraclostridium bifermentans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8BGM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8BGM FirstGlance]. <br> | ||
| + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8bgm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8bgm OCA], [https://pdbe.org/8bgm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8bgm RCSB], [https://www.ebi.ac.uk/pdbsum/8bgm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8bgm ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/A0A5P3XKM0_PARBF A0A5P3XKM0_PARBF] | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Paraclostridial mosquitocidal protein 1 (PMP1) is a member of the clostridial neurotoxin (CNT) family, which includes botulinum and tetanus neurotoxins. PMP1 has unique selectivity for anopheline mosquitos and is the only known member of the family that targets insects. PMP1 is encoded in an orfX gene cluster, which in addition to the toxin, consists of OrfX1, OrfX2, OrfX3, P47 and NTNH, which have been shown to aid in PMP1 toxicity. We here show that OrfX1 and OrfX3 form a complex and present its structure at 2.7 A. The OrfX1-OrfX3 complex mimics the structure of full-length OrfX2 and belongs to the lipid-binding TULIP protein superfamily. With this report, the structures of all proteins encoded in the orfX gene cluster of CNTs are now determined. | ||
| - | + | Crystal structure of the OrfX1-OrfX3 complex from the PMP1 neurotoxin gene cluster.,Kosenina S, Stenmark P FEBS Lett. 2022 Nov 20. doi: 10.1002/1873-3468.14542. PMID:36403098<ref>PMID:36403098</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | [[Category: | + | </div> |
| + | <div class="pdbe-citations 8bgm" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Paraclostridium bifermentans]] | ||
| + | [[Category: Kosenina S]] | ||
| + | [[Category: Stenmark P]] | ||
Revision as of 08:20, 7 December 2022
Crystal structure of the OrfX1-OrfX3 complex from the PMP1 neurotoxin gene cluster
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