8dl8

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'''Unreleased structure'''
 
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The entry 8dl8 is ON HOLD until Paper Publication
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==Cryo-EM structure of human ferroportin/slc40 bound to Co2+ in nanodisc==
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<StructureSection load='8dl8' size='340' side='right'caption='[[8dl8]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
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Authors: Shen, J., Wilbon, A.S., Pan, Y., Zhou, M.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[8dl8]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8DL8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8DL8 FirstGlance]. <br>
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Description: Cryo-EM structure of human ferroportin/slc40 bound to Co2+ in nanodisc
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8dl8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8dl8 OCA], [https://pdbe.org/8dl8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8dl8 RCSB], [https://www.ebi.ac.uk/pdbsum/8dl8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8dl8 ProSAT]</span></td></tr>
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[[Category: Pan, Y]]
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</table>
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[[Category: Wilbon, A.S]]
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== Disease ==
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[[Category: Zhou, M]]
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[https://www.uniprot.org/uniprot/S40A1_HUMAN S40A1_HUMAN] Hemochromatosis type 4. The disease is caused by variants affecting the gene represented in this entry.
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[[Category: Shen, J]]
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== Function ==
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[https://www.uniprot.org/uniprot/S40A1_HUMAN S40A1_HUMAN] Major iron transporter that plays a key role in balancing cellular and systemic iron levels (PubMed:29237594, PubMed:22682227, PubMed:15692071). Transports iron from intestinal, splenic, and hepatic cells into the blood to provide iron to other tissues (By similarity). Controls therefore dietary iron uptake, iron recycling by macrophages, and release of iron stores in hepatocytes (By similarity). When iron is in excess, hepcidin/HAMP levels increase resulting in a degradation of ferroportin/SLC40A1 limiting the iron efflux to plasma (PubMed:22682227, PubMed:29237594, PubMed:32814342).[UniProtKB:Q9JHI9]<ref>PMID:15692071</ref> <ref>PMID:22682227</ref> <ref>PMID:29237594</ref> <ref>PMID:32814342</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Mus musculus]]
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[[Category: Pan Y]]
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[[Category: Shen J]]
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[[Category: Wilbon AS]]
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[[Category: Zhou M]]

Revision as of 08:20, 7 December 2022

Cryo-EM structure of human ferroportin/slc40 bound to Co2+ in nanodisc

PDB ID 8dl8

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