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6xu2

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<StructureSection load='6xu2' size='340' side='right'caption='[[6xu2]], [[Resolution|resolution]] 2.83&Aring;' scene=''>
<StructureSection load='6xu2' size='340' side='right'caption='[[6xu2]], [[Resolution|resolution]] 2.83&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6xu2]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6XU2 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6XU2 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6xu2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Actinomycetia Actinomycetia] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6XU2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6XU2 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene>, <scene name='pdbligand=OAR:N-(4-AMINO-5-HYDROXY-PENTYL)-GUANIDINE'>OAR</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FC0:N-CARBOXY-L-PHENYLALANINE'>FC0</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene>, <scene name='pdbligand=RGL:ARGINAL'>RGL</scene></td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=FC0:N-CARBOXY-L-PHENYLALANINE'>FC0</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6xu2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6xu2 OCA], [https://pdbe.org/6xu2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6xu2 RCSB], [https://www.ebi.ac.uk/pdbsum/6xu2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6xu2 ProSAT]</span></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">IPO5, KPNB3, RANBP5 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6xu2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6xu2 OCA], [http://pdbe.org/6xu2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6xu2 RCSB], [http://www.ebi.ac.uk/pdbsum/6xu2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6xu2 ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/IPO5_HUMAN IPO5_HUMAN]] Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Mediates the nuclear import of ribosomal proteins RPL23A, RPS7 and RPL5. Binds to a beta-like import receptor binding (BIB) domain of RPL23A. In vitro, mediates nuclear import of H2A, H2B, H3 and H4 histones. Binds to CPEB3 and mediates its nuclear import following neuronal stimulation (By similarity). In case of HIV-1 infection, binds and mediates the nuclear import of HIV-1 Rev.[UniProtKB:Q8BKC5]<ref>PMID:9687515</ref>
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[https://www.uniprot.org/uniprot/IPO5_HUMAN IPO5_HUMAN] Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Mediates the nuclear import of ribosomal proteins RPL23A, RPS7 and RPL5. Binds to a beta-like import receptor binding (BIB) domain of RPL23A. In vitro, mediates nuclear import of H2A, H2B, H3 and H4 histones. Binds to CPEB3 and mediates its nuclear import following neuronal stimulation (By similarity). In case of HIV-1 infection, binds and mediates the nuclear import of HIV-1 Rev.[UniProtKB:Q8BKC5]<ref>PMID:9687515</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 6xu2" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 6xu2" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Importin 3D structures|Importin 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Actinomycetia]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Berger, I]]
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[[Category: Berger I]]
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[[Category: Bieniossek, C]]
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[[Category: Bieniossek C]]
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[[Category: Crepin, T]]
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[[Category: Crepin T]]
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[[Category: Delmas, B]]
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[[Category: Delmas B]]
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[[Category: McCarthy, A A]]
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[[Category: McCarthy AA]]
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[[Category: Ruigrok, R W.H]]
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[[Category: Ruigrok RWH]]
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[[Category: Swale, C]]
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[[Category: Swale C]]
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[[Category: Host-pathogen interaction]]
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[[Category: Human karyopherin]]
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[[Category: Influenza polymerase assembly]]
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[[Category: Pa-pb1 sub-complex nuclear import]]
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[[Category: Translocase]]
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Revision as of 08:27, 7 December 2022

Human karyopherin RanBP5 (isoform-3)

PDB ID 6xu2

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