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7oxf

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Current revision (08:29, 7 December 2022) (edit) (undo)
 
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== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/APAM_APIME APAM_APIME]] Neurotoxin that blocks the small-conductance calcium-activated potassium (SK) channels KCa2.1/KCNN1/SK1, KCa2.2/KCNN2/SK2 and KCa2.3/KCNN3/SK3 (PubMed:6122211, PubMed:9459560, PubMed:9287325, PubMed:10696100, PubMed:11533126, PubMed:11212219, PubMed:17142458, PubMed:20562108, PubMed:32560481). Also irreversibly blocks the voltage-gated potassium channel Kv1.3/KCNA3 (IC(50)=13 nM) (PubMed:28108814). Potently blocks human, rat and mouse KCa2.2/KCNN2/SK2 channels (IC(50)=27-140 pM), and moderately blocks human and rat KCa2.3/KCNN3/SK3 channels (IC(50)=0.6-4 nM), and human (IC(50)=0.7-12 nM) and mouse (IC(50)=28 nM) KCa2.1/KCNN1/SK1 channels (PubMed:9459560, PubMed:9287325, PubMed:10696100, PubMed:11533126, PubMed:11212219, PubMed:17142458, PubMed:20562108). However, other reports found that it did not block the human KCa2.1/KCNN1/SK1 channels (PubMed:9287325). Also able to inhibit neuromuscular transmission by a mechanism independent of the blockade of SK channels, which may involve the activation of inhibitory muscarinic M2 receptors on motor nerve terminals (PubMed:19818752).<ref>PMID:10696100</ref> <ref>PMID:11212219</ref> <ref>PMID:11533126</ref> <ref>PMID:17142458</ref> <ref>PMID:19818752</ref> <ref>PMID:20562108</ref> <ref>PMID:28108814</ref> <ref>PMID:32560481</ref> <ref>PMID:6122211</ref> <ref>PMID:9287325</ref> <ref>PMID:9459560</ref>
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[https://www.uniprot.org/uniprot/APAM_APIME APAM_APIME] Neurotoxin that blocks the small-conductance calcium-activated potassium (SK) channels KCa2.1/KCNN1/SK1, KCa2.2/KCNN2/SK2 and KCa2.3/KCNN3/SK3 (PubMed:6122211, PubMed:9459560, PubMed:9287325, PubMed:10696100, PubMed:11533126, PubMed:11212219, PubMed:17142458, PubMed:20562108, PubMed:32560481). Also irreversibly blocks the voltage-gated potassium channel Kv1.3/KCNA3 (IC(50)=13 nM) (PubMed:28108814). Potently blocks human, rat and mouse KCa2.2/KCNN2/SK2 channels (IC(50)=27-140 pM), and moderately blocks human and rat KCa2.3/KCNN3/SK3 channels (IC(50)=0.6-4 nM), and human (IC(50)=0.7-12 nM) and mouse (IC(50)=28 nM) KCa2.1/KCNN1/SK1 channels (PubMed:9459560, PubMed:9287325, PubMed:10696100, PubMed:11533126, PubMed:11212219, PubMed:17142458, PubMed:20562108). However, other reports found that it did not block the human KCa2.1/KCNN1/SK1 channels (PubMed:9287325). Also able to inhibit neuromuscular transmission by a mechanism independent of the blockade of SK channels, which may involve the activation of inhibitory muscarinic M2 receptors on motor nerve terminals (PubMed:19818752).<ref>PMID:10696100</ref> <ref>PMID:11212219</ref> <ref>PMID:11533126</ref> <ref>PMID:17142458</ref> <ref>PMID:19818752</ref> <ref>PMID:20562108</ref> <ref>PMID:28108814</ref> <ref>PMID:32560481</ref> <ref>PMID:6122211</ref> <ref>PMID:9287325</ref> <ref>PMID:9459560</ref>
== References ==
== References ==
<references/>
<references/>

Current revision

Solution structure of bee apamin

PDB ID 7oxf

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