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From Proteopedia
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== Disease == | == Disease == | ||
| - | + | [https://www.uniprot.org/uniprot/FPR1_HUMAN FPR1_HUMAN] Susceptibility to localized juvenile periodontitis. | |
== Function == | == Function == | ||
| - | + | [https://www.uniprot.org/uniprot/FPR1_HUMAN FPR1_HUMAN] High affinity receptor for N-formyl-methionyl peptides (fMLP), which are powerful neutrophil chemotactic factors (PubMed:2161213, PubMed:2176894, PubMed:10514456, PubMed:15153520). Binding of fMLP to the receptor stimulates intracellular calcium mobilization and superoxide anion release (PubMed:2161213, PubMed:1712023, PubMed:15153520, PubMed:15210802). This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system (PubMed:1712023, PubMed:10514456). Receptor for TAFA4, mediates its effects on chemoattracting macrophages, promoting phagocytosis and increasing ROS release (PubMed:25109685). Receptor for cathepsin CTSG, leading to increased phagocyte chemotaxis (PubMed:15210802).<ref>PMID:10514456</ref> <ref>PMID:15153520</ref> <ref>PMID:2161213</ref> <ref>PMID:2176894</ref> <ref>PMID:25109685</ref> <ref>PMID:10514456</ref> <ref>PMID:1712023</ref> <ref>PMID:2161213</ref> <ref>PMID:2176894</ref> | |
== References == | == References == | ||
<references/> | <references/> | ||
Current revision
The structure of Formyl Peptide Receptor 1 in complex with Gi and peptide agonist fMIFL
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Categories: Homo sapiens | Large Structures | Mus musculus | Staphylococcus aureus | Chen G | Du Y | Hu HL | Liao QW | Wang XK | Ye DQ
