7vfx

Structural highlights

Disease

FPR1_HUMAN Susceptibility to localized juvenile periodontitis.

Function

FPR1_HUMAN High affinity receptor for N-formyl-methionyl peptides (fMLP), which are powerful neutrophil chemotactic factors (PubMed:2161213, PubMed:2176894, PubMed:10514456, PubMed:15153520). Binding of fMLP to the receptor stimulates intracellular calcium mobilization and superoxide anion release (PubMed:2161213, PubMed:1712023, PubMed:15153520, PubMed:15210802). This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system (PubMed:1712023, PubMed:10514456). Receptor for TAFA4, mediates its effects on chemoattracting macrophages, promoting phagocytosis and increasing ROS release (PubMed:25109685). Receptor for cathepsin CTSG, leading to increased phagocyte chemotaxis (PubMed:15210802).^{[1] [2] [3] [4] [5] [6] [7] [8] [9]}

References

1. ↑ Maestes DC, Potter RM, Prossnitz ER. Differential phosphorylation paradigms dictate desensitization and internalization of the N-formyl peptide receptor. J Biol Chem. 1999 Oct 15;274(42):29791-5. doi: 10.1074/jbc.274.42.29791. PMID:10514456 doi:http://dx.doi.org/10.1074/jbc.274.42.29791
2. ↑ Postma B, Poppelier MJ, van Galen JC, Prossnitz ER, van Strijp JA, de Haas CJ, van Kessel KP. Chemotaxis inhibitory protein of Staphylococcus aureus binds specifically to the C5a and formylated peptide receptor. J Immunol. 2004 Jun 1;172(11):6994-7001. PMID:15153520
3. ↑ Boulay F, Tardif M, Brouchon L, Vignais P. Synthesis and use of a novel N-formyl peptide derivative to isolate a human N-formyl peptide receptor cDNA. Biochem Biophys Res Commun. 1990 May 16;168(3):1103-9. doi:, 10.1016/0006-291x(90)91143-g. PMID:2161213 doi:http://dx.doi.org/10.1016/0006-291x(90)91143-g
4. ↑ Boulay F, Tardif M, Brouchon L, Vignais P. The human N-formylpeptide receptor. Characterization of two cDNA isolates and evidence for a new subfamily of G-protein-coupled receptors. Biochemistry. 1990 Dec 18;29(50):11123-33. doi: 10.1021/bi00502a016. PMID:2176894 doi:http://dx.doi.org/10.1021/bi00502a016
5. ↑ Wang W, Li T, Wang X, Yuan W, Cheng Y, Zhang H, Xu E, Zhang Y, Shi S, Ma D, Han W. FAM19A4 is a novel cytokine ligand of formyl peptide receptor 1 (FPR1) and is able to promote the migration and phagocytosis of macrophages. Cell Mol Immunol. 2015 Sep;12(5):615-24. doi: 10.1038/cmi.2014.61. Epub 2014 Aug , 11. PMID:25109685 doi:http://dx.doi.org/10.1038/cmi.2014.61
6. ↑ Maestes DC, Potter RM, Prossnitz ER. Differential phosphorylation paradigms dictate desensitization and internalization of the N-formyl peptide receptor. J Biol Chem. 1999 Oct 15;274(42):29791-5. doi: 10.1074/jbc.274.42.29791. PMID:10514456 doi:http://dx.doi.org/10.1074/jbc.274.42.29791
7. ↑ Murphy PM, McDermott D. Functional expression of the human formyl peptide receptor in Xenopus oocytes requires a complementary human factor. J Biol Chem. 1991 Jul 5;266(19):12560-7. PMID:1712023
8. ↑ Boulay F, Tardif M, Brouchon L, Vignais P. Synthesis and use of a novel N-formyl peptide derivative to isolate a human N-formyl peptide receptor cDNA. Biochem Biophys Res Commun. 1990 May 16;168(3):1103-9. doi:, 10.1016/0006-291x(90)91143-g. PMID:2161213 doi:http://dx.doi.org/10.1016/0006-291x(90)91143-g
9. ↑ Boulay F, Tardif M, Brouchon L, Vignais P. The human N-formylpeptide receptor. Characterization of two cDNA isolates and evidence for a new subfamily of G-protein-coupled receptors. Biochemistry. 1990 Dec 18;29(50):11123-33. doi: 10.1021/bi00502a016. PMID:2176894 doi:http://dx.doi.org/10.1021/bi00502a016