1hrp
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(New page: 200px<br /> <applet load="1hrp" size="450" color="white" frame="true" align="right" spinBox="true" caption="1hrp, resolution 3.0Å" /> '''CRYSTAL STRUCTURE OF...)
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Revision as of 15:15, 12 November 2007
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CRYSTAL STRUCTURE OF HUMAN CHORIONIC GONADOTROPIN
Overview
The three-dimensional structure of human chorionic gonadotropin shows that, each of its two different subunits has a similar topology, with three, disulphide bonds forming a cystine knot. This same folding motif is found, in some protein growth factors. The heterodimer is stabilized by a segment, of the beta-subunit which wraps around the alpha-subunit and is covalently, linked like a seat belt by the disulphide Cys 26-Cys 110. This, extraordinary feature appears to be essential not only for the association, of these heterodimers but also for receptor binding by the glycoprotein, hormones.
About this Structure
1HRP is a Protein complex structure of sequences from [1] with NAG as ligand. Full crystallographic information is available from OCA.
Reference
Crystal structure of human chorionic gonadotropin., Lapthorn AJ, Harris DC, Littlejohn A, Lustbader JW, Canfield RE, Machin KJ, Morgan FJ, Isaacs NW, Nature. 1994 Jun 9;369(6480):455-61. PMID:8202136
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