1j9k

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[[Image:1j9k.jpg|left|200px]]
[[Image:1j9k.jpg|left|200px]]
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{{Structure
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|PDB= 1j9k |SIZE=350|CAPTION= <scene name='initialview01'>1j9k</scene>, resolution 2.10&Aring;
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The line below this paragraph, containing "STRUCTURE_1j9k", creates the "Structure Box" on the page.
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|LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=WO4:TUNGSTATE(VI)ION'>WO4</scene>
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{{STRUCTURE_1j9k| PDB=1j9k | SCENE= }}
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|RELATEDENTRY=[[1j9j|1J9J]], [[1j9l|1J9L]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1j9k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1j9k OCA], [http://www.ebi.ac.uk/pdbsum/1j9k PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1j9k RCSB]</span>
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'''CRYSTAL STRUCTURE OF SURE PROTEIN FROM T.MARITIMA IN COMPLEX WITH TUNGSTATE'''
'''CRYSTAL STRUCTURE OF SURE PROTEIN FROM T.MARITIMA IN COMPLEX WITH TUNGSTATE'''
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[[Category: Moon, J.]]
[[Category: Moon, J.]]
[[Category: Suh, S W.]]
[[Category: Suh, S W.]]
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[[Category: sure protein]]
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[[Category: Sure protein]]
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[[Category: tungstate complex]]
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[[Category: Tungstate complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 20:57:08 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:30:30 2008''
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Revision as of 17:57, 2 May 2008

Image:1j9k.jpg

Template:STRUCTURE 1j9k

CRYSTAL STRUCTURE OF SURE PROTEIN FROM T.MARITIMA IN COMPLEX WITH TUNGSTATE


Overview

Homologs of the Escherichia coli surE gene are present in many eubacteria and archaea. Despite the evolutionary conservation, little information is available on the structure and function of their gene products. We have determined the crystal structure of the SurE protein from Thermotoga maritima. The structure reveals the dimeric arrangement of the subunits and an active site around a bound metal ion. We also demonstrate that the SurE protein exhibits a divalent metal ion-dependent phosphatase activity that is inhibited by vanadate or tungstate. In the vanadate- and tungstate-complexed structures, the inhibitors bind adjacent to the divalent metal ion. Our structural and functional analyses identify the SurE proteins as a novel family of metal ion-dependent phosphatases.

About this Structure

1J9K is a Single protein structure of sequence from Thermotoga maritima. Full crystallographic information is available from OCA.

Reference

Crystal structure and functional analysis of the SurE protein identify a novel phosphatase family., Lee JY, Kwak JE, Moon J, Eom SH, Liong EC, Pedelacq JD, Berendzen J, Suh SW, Nat Struct Biol. 2001 Sep;8(9):789-94. PMID:11524683 Page seeded by OCA on Fri May 2 20:57:08 2008

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