4kt8

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==The complex structure of Rv3378c-Y51FY90F with substrate, TPP==
==The complex structure of Rv3378c-Y51FY90F with substrate, TPP==
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<StructureSection load='4kt8' size='340' side='right' caption='[[4kt8]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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<StructureSection load='4kt8' size='340' side='right'caption='[[4kt8]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4kt8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_tuberculosis"_(zopf_1883)_klein_1884 "bacillus tuberculosis" (zopf 1883) klein 1884]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KT8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4KT8 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4kt8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KT8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4KT8 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=9AX:(2E)-3-methyl-5-[(1R,2S,8aS)-1,2,5,5-tetramethyl-1,2,3,5,6,7,8,8a-octahydronaphthalen-1-yl]pent-2-en-1-yl+trihydrogen+diphosphate'>9AX</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=9AX:(2E)-3-methyl-5-[(1R,2S,8aS)-1,2,5,5-tetramethyl-1,2,3,5,6,7,8,8a-octahydronaphthalen-1-yl]pent-2-en-1-yl+trihydrogen+diphosphate'>9AX</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3vx5|3vx5]], [[3vxa|3vxa]], [[3vx9|3vx9]], [[3w3i|3w3i]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4kt8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kt8 OCA], [https://pdbe.org/4kt8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4kt8 RCSB], [https://www.ebi.ac.uk/pdbsum/4kt8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4kt8 ProSAT]</span></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Rv3378c, MT3488 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 "Bacillus tuberculosis" (Zopf 1883) Klein 1884])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4kt8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kt8 OCA], [http://pdbe.org/4kt8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4kt8 RCSB], [http://www.ebi.ac.uk/pdbsum/4kt8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4kt8 ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/TUBOL_MYCTU TUBOL_MYCTU]] Catalyzes the PP-removal from tuberculosinyl diphosphate to produce both tubercilosinol and isotuberculosinol. Can also use labdadienyl diphosphates, copalyl diphosphate (CDP), ent-CDP and syn-CDP in vitro.
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[https://www.uniprot.org/uniprot/TUBAT_MYCTU TUBAT_MYCTU] Tuberculosinyl transferase that catalyzes the condensation of adenosine and tuberculosinyl diphosphate (TbPP) to generate 1-tuberculosinyladenosine (1-TbAd), which acts as an antiacid that directly protects M.tuberculosis from acid pH and physically remodels M.tuberculosis phagolysosomes (PubMed:24516143, PubMed:31427817). In addition, acts as a phosphatase that catalyzes the diphosphate-removal from TbPP to produce both tuberculosinol (TOH) and isotuberculosinol (iso-TOH) (PubMed:21228491, PubMed:24475925). Has broad substrate specificity, and can also use the 3 labdadienyl diphosphates, copalyl diphosphate (CDP), ent-CDP and syn-CDP in vitro (PubMed:21290071).<ref>PMID:21228491</ref> <ref>PMID:21290071</ref> <ref>PMID:24475925</ref> <ref>PMID:24516143</ref> <ref>PMID:31427817</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Bogue, S]]
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[[Category: Large Structures]]
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[[Category: Chan, H C]]
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[[Category: Mycobacterium tuberculosis]]
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[[Category: Crick, D C]]
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[[Category: Bogue S]]
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[[Category: Feng, X]]
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[[Category: Chan HC]]
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[[Category: Guo, R T]]
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[[Category: Crick DC]]
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[[Category: Hoshino, T]]
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[[Category: Feng X]]
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[[Category: Hu, Y]]
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[[Category: Guo RT]]
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[[Category: Huang, C H]]
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[[Category: Hoshino T]]
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[[Category: Ko, T P]]
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[[Category: Hu Y]]
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[[Category: Liang, P H]]
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[[Category: Huang CH]]
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[[Category: Liu, W]]
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[[Category: Ko TP]]
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[[Category: Lv, P]]
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[[Category: Liang PH]]
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[[Category: Nakano, C]]
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[[Category: Liu W]]
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[[Category: Oldfield, E]]
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[[Category: Lv P]]
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[[Category: Wang, A H]]
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[[Category: Nakano C]]
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[[Category: Zhang, L]]
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[[Category: Oldfield E]]
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[[Category: Zheng, Y]]
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[[Category: Wang AH]]
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[[Category: Diterpene synthase]]
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[[Category: Zhang L]]
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[[Category: Hydrolase]]
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[[Category: Zheng Y]]

Revision as of 09:12, 7 December 2022

The complex structure of Rv3378c-Y51FY90F with substrate, TPP

PDB ID 4kt8

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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