4l0o

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==Structure determination of cystathionine gamma-synthase from Helicobacter pylori==
==Structure determination of cystathionine gamma-synthase from Helicobacter pylori==
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<StructureSection load='4l0o' size='340' side='right' caption='[[4l0o]], [[Resolution|resolution]] 2.76&Aring;' scene=''>
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<StructureSection load='4l0o' size='340' side='right'caption='[[4l0o]], [[Resolution|resolution]] 2.76&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4l0o]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Campylobacter_pylori Campylobacter pylori]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4L0O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4L0O FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4l0o]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Helicobacter_pylori_26695 Helicobacter pylori 26695]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4L0O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4L0O FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">cystathionine gamma-synthase, HP_0106, metB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=85962 Campylobacter pylori])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4l0o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4l0o OCA], [https://pdbe.org/4l0o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4l0o RCSB], [https://www.ebi.ac.uk/pdbsum/4l0o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4l0o ProSAT]</span></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cystathionine_gamma-synthase Cystathionine gamma-synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.48 2.5.1.48] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4l0o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4l0o OCA], [http://pdbe.org/4l0o PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4l0o RCSB], [http://www.ebi.ac.uk/pdbsum/4l0o PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4l0o ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/METB_HELPY METB_HELPY]] Catalyzes the formation of L-cystathionine from O-succinyl-L-homoserine (OSHS) and L-cysteine, via a gamma-replacement reaction. In the absence of thiol, catalyzes gamma-elimination to form 2-oxobutanoate, succinate and ammonia (By similarity).
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[https://www.uniprot.org/uniprot/METB_HELPY METB_HELPY] Catalyzes the formation of L-cystathionine from O-succinyl-L-homoserine (OSHS) and L-cysteine, via a gamma-replacement reaction. In the absence of thiol, catalyzes gamma-elimination to form 2-oxobutanoate, succinate and ammonia (By similarity).
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==See Also==
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*[[Cystathionine gamma synthase|Cystathionine gamma synthase]]
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Campylobacter pylori]]
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[[Category: Helicobacter pylori 26695]]
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[[Category: Cystathionine gamma-synthase]]
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[[Category: Large Structures]]
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[[Category: Gourinath, S]]
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[[Category: Gourinath S]]
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[[Category: Rehman, S A.A]]
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[[Category: Rehman SAA]]
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[[Category: Tarique, K F]]
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[[Category: Tarique KF]]
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[[Category: C-s bond cleavage]]
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[[Category: Elimination]]
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[[Category: Lyase]]
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Revision as of 09:24, 7 December 2022

Structure determination of cystathionine gamma-synthase from Helicobacter pylori

PDB ID 4l0o

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