4l1a

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==Crystallographic study of multi-drug resistant HIV-1 protease Lopinavir complex: mechanism of drug recognition and resistance==
==Crystallographic study of multi-drug resistant HIV-1 protease Lopinavir complex: mechanism of drug recognition and resistance==
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<StructureSection load='4l1a' size='340' side='right' caption='[[4l1a]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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<StructureSection load='4l1a' size='340' side='right'caption='[[4l1a]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4l1a]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/9hiv1 9hiv1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4L1A OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4L1A FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4l1a]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4L1A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4L1A FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AB1:N-{1-BENZYL-4-[2-(2,6-DIMETHYL-PHENOXY)-ACETYLAMINO]-3-HYDROXY-5-PHENYL-PENTYL}-3-METHYL-2-(2-OXO-TETRAHYDRO-PYRIMIDIN-1-YL)-BUTYRAMIDE'>AB1</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AB1:N-{1-BENZYL-4-[2-(2,6-DIMETHYL-PHENOXY)-ACETYLAMINO]-3-HYDROXY-5-PHENYL-PENTYL}-3-METHYL-2-(2-OXO-TETRAHYDRO-PYRIMIDIN-1-YL)-BUTYRAMIDE'>AB1</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">pol ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11676 9HIV1])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4l1a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4l1a OCA], [https://pdbe.org/4l1a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4l1a RCSB], [https://www.ebi.ac.uk/pdbsum/4l1a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4l1a ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4l1a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4l1a OCA], [http://pdbe.org/4l1a PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4l1a RCSB], [http://www.ebi.ac.uk/pdbsum/4l1a PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4l1a ProSAT]</span></td></tr>
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</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q000H7_9HIV1 Q000H7_9HIV1]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 4l1a" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 4l1a" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Immunodeficiency virus protease 3D structures|Immunodeficiency virus protease 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Brunzelle, J]]
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[[Category: Human immunodeficiency virus 1]]
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[[Category: Dewdney, T]]
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[[Category: Large Structures]]
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[[Category: Kovari, I]]
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[[Category: Brunzelle J]]
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[[Category: Kovari, L]]
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[[Category: Dewdney T]]
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[[Category: Liu, Z]]
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[[Category: Kovari I]]
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[[Category: Reiter, S]]
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[[Category: Kovari L]]
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[[Category: Wang, Y]]
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[[Category: Liu Z]]
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[[Category: Yedidi, R S]]
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[[Category: Reiter S]]
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[[Category: Hiv-1 protease]]
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[[Category: Wang Y]]
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[[Category: Hydrolase-hydrolase inhibitor complex]]
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[[Category: Yedidi RS]]
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[[Category: Ic50]]
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[[Category: Lopinavir]]
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[[Category: Multi-drug resistance]]
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[[Category: Protease]]
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Revision as of 09:25, 7 December 2022

Crystallographic study of multi-drug resistant HIV-1 protease Lopinavir complex: mechanism of drug recognition and resistance

PDB ID 4l1a

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