4l1m

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
==Structure of the first RCC1-like domain of HERC2==
==Structure of the first RCC1-like domain of HERC2==
-
<StructureSection load='4l1m' size='340' side='right' caption='[[4l1m]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
+
<StructureSection load='4l1m' size='340' side='right'caption='[[4l1m]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[4l1m]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4L1M OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4L1M FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[4l1m]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4L1M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4L1M FirstGlance]. <br>
-
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
+
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
-
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">HERC2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4l1m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4l1m OCA], [https://pdbe.org/4l1m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4l1m RCSB], [https://www.ebi.ac.uk/pdbsum/4l1m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4l1m ProSAT]</span></td></tr>
-
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4l1m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4l1m OCA], [http://pdbe.org/4l1m PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4l1m RCSB], [http://www.ebi.ac.uk/pdbsum/4l1m PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4l1m ProSAT]</span></td></tr>
+
</table>
</table>
== Function ==
== Function ==
-
[[http://www.uniprot.org/uniprot/HERC2_HUMAN HERC2_HUMAN]] E3 ubiquitin-protein ligase that regulates ubiquitin-dependent retention of repair proteins on damaged chromosomes. Recruited to sites of DNA damage in response to ionizing radiation (IR) and facilitates the assembly of UBE2N and RNF8 promoting DNA damage-induced formation of 'Lys-63'-linked ubiquitin chains. Acts as a mediator of binding specificity between UBE2N and RNF8. Involved in the maintenance of RNF168 levels. E3 ubiquitin-protein ligase that promotes the ubiquitination and proteasomal degradation of XPA which influences the circadian oscillation of DNA excision repair activity.<ref>PMID:20023648</ref> <ref>PMID:20304803</ref> <ref>PMID:22508508</ref>
+
[https://www.uniprot.org/uniprot/HERC2_HUMAN HERC2_HUMAN] E3 ubiquitin-protein ligase that regulates ubiquitin-dependent retention of repair proteins on damaged chromosomes. Recruited to sites of DNA damage in response to ionizing radiation (IR) and facilitates the assembly of UBE2N and RNF8 promoting DNA damage-induced formation of 'Lys-63'-linked ubiquitin chains. Acts as a mediator of binding specificity between UBE2N and RNF8. Involved in the maintenance of RNF168 levels. E3 ubiquitin-protein ligase that promotes the ubiquitination and proteasomal degradation of XPA which influences the circadian oscillation of DNA excision repair activity.<ref>PMID:20023648</ref> <ref>PMID:20304803</ref> <ref>PMID:22508508</ref>
==See Also==
==See Also==
-
*[[Ubiquitin protein ligase|Ubiquitin protein ligase]]
+
*[[Ubiquitin protein ligase 3D structures|Ubiquitin protein ligase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
-
[[Category: Human]]
+
[[Category: Homo sapiens]]
-
[[Category: Arrowsmith, C H]]
+
[[Category: Large Structures]]
-
[[Category: Bountra, C]]
+
[[Category: Arrowsmith CH]]
-
[[Category: Dong, A]]
+
[[Category: Bountra C]]
-
[[Category: Edwards, A M]]
+
[[Category: Dong A]]
-
[[Category: Hu, J]]
+
[[Category: Edwards AM]]
-
[[Category: Khan, M B]]
+
[[Category: Hu J]]
-
[[Category: Li, Y]]
+
[[Category: Khan MB]]
-
[[Category: Structural genomic]]
+
[[Category: Li Y]]
-
[[Category: Tempel, W]]
+
[[Category: Tempel W]]
-
[[Category: Tong, Y]]
+
[[Category: Tong Y]]
-
[[Category: Beta-propeller]]
+
-
[[Category: Herc2]]
+
-
[[Category: Ligase]]
+
-
[[Category: Rcc1]]
+
-
[[Category: Rld]]
+
-
[[Category: Sgc]]
+

Revision as of 09:27, 7 December 2022

Structure of the first RCC1-like domain of HERC2

PDB ID 4l1m

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4l1m"
Personal tools