4l2x

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==Crystal structure of human FPPS in complex with magnesium, CL02134, and inorganic pyrophosphate==
==Crystal structure of human FPPS in complex with magnesium, CL02134, and inorganic pyrophosphate==
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<StructureSection load='4l2x' size='340' side='right' caption='[[4l2x]], [[Resolution|resolution]] 2.55&Aring;' scene=''>
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<StructureSection load='4l2x' size='340' side='right'caption='[[4l2x]], [[Resolution|resolution]] 2.55&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4l2x]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4L2X OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4L2X FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4l2x]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4L2X OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4L2X FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=POP:PYROPHOSPHATE+2-'>POP</scene>, <scene name='pdbligand=YL2:({[6-(4-CYCLOPROPYLPHENYL)THIENO[2,3-D]PYRIMIDIN-4-YL]AMINO}METHANEDIYL)BIS(PHOSPHONIC+ACID)'>YL2</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=POP:PYROPHOSPHATE+2-'>POP</scene>, <scene name='pdbligand=YL2:({[6-(4-CYCLOPROPYLPHENYL)THIENO[2,3-D]PYRIMIDIN-4-YL]AMINO}METHANEDIYL)BIS(PHOSPHONIC+ACID)'>YL2</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4jvj|4jvj]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4l2x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4l2x OCA], [https://pdbe.org/4l2x PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4l2x RCSB], [https://www.ebi.ac.uk/pdbsum/4l2x PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4l2x ProSAT]</span></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">FDPS, FPS, KIAA1293 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4l2x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4l2x OCA], [http://pdbe.org/4l2x PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4l2x RCSB], [http://www.ebi.ac.uk/pdbsum/4l2x PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4l2x ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/FPPS_HUMAN FPPS_HUMAN]] Key enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate (FPP), a precursor for several classes of essential metabolites including sterols, dolichols, carotenoids, and ubiquinones. FPP also serves as substrate for protein farnesylation and geranylgeranylation. Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate.
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[https://www.uniprot.org/uniprot/FPPS_HUMAN FPPS_HUMAN] Key enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate (FPP), a precursor for several classes of essential metabolites including sterols, dolichols, carotenoids, and ubiquinones. FPP also serves as substrate for protein farnesylation and geranylgeranylation. Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 4l2x" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 4l2x" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Farnesyl diphosphate synthase 3D structures|Farnesyl diphosphate synthase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
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[[Category: Berghuis, A M]]
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[[Category: Large Structures]]
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[[Category: Leung, C Y]]
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[[Category: Berghuis AM]]
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[[Category: Park, J]]
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[[Category: Leung C-Y]]
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[[Category: Tsantrizos, Y S]]
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[[Category: Park J]]
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[[Category: Transferase-transferase inhibitor complex]]
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[[Category: Tsantrizos YS]]

Revision as of 09:28, 7 December 2022

Crystal structure of human FPPS in complex with magnesium, CL02134, and inorganic pyrophosphate

PDB ID 4l2x

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