1jaj
From Proteopedia
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'''Solution Structure of DNA Polymerase X from the African Swine Fever Virus''' | '''Solution Structure of DNA Polymerase X from the African Swine Fever Virus''' | ||
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[[Category: Pan, B.]] | [[Category: Pan, B.]] | ||
[[Category: Shin, R.]] | [[Category: Shin, R.]] | ||
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Revision as of 17:58, 2 May 2008
Solution Structure of DNA Polymerase X from the African Swine Fever Virus
Overview
DNA polymerase X (Pol X) from the African swine fever virus (ASFV) specifically binds intermediates in the single-nucleotide base-excision repair process, an activity indicative of repair function. In addition, Pol X catalyzes DNA polymerization with low nucleotide-insertion fidelity. The structural mechanisms by which DNA polymerases confer high or low fidelity in DNA polymerization remain to be elucidated. The three-dimensional structure of Pol X has been determined. Unlike other DNA polymerases, Pol X is formed from only a palm and a C-terminal subdomain. Pol X has a novel palm subdomain fold, containing a positively charged helix at the DNA binding surface. Purine deoxynucleoside triphosphate (dNTP) substrates bind between the palm and C-terminal subdomain, at a dNTP-binding helix, and induce a unique conformation in Pol X. The purine dNTP-bound conformation and high binding affinity for dGTP-Mg(2+) of Pol X may contribute to its low fidelity.
About this Structure
1JAJ is a Single protein structure of sequence from African swine fever virus. Full crystallographic information is available from OCA.
Reference
Solution structure of a viral DNA repair polymerase., Maciejewski MW, Shin R, Pan B, Marintchev A, Denninger A, Mullen MA, Chen K, Gryk MR, Mullen GP, Nat Struct Biol. 2001 Nov;8(11):936-41. PMID:11685238 Page seeded by OCA on Fri May 2 20:58:55 2008
