4l4h

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==Crystal structure of mouse Ryanodine Receptor isoform 2 (RyR2) 1-547==
==Crystal structure of mouse Ryanodine Receptor isoform 2 (RyR2) 1-547==
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<StructureSection load='4l4h' size='340' side='right' caption='[[4l4h]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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<StructureSection load='4l4h' size='340' side='right'caption='[[4l4h]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4l4h]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4L4H OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4L4H FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4l4h]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4L4H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4L4H FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4l4i|4l4i]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4l4h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4l4h OCA], [https://pdbe.org/4l4h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4l4h RCSB], [https://www.ebi.ac.uk/pdbsum/4l4h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4l4h ProSAT]</span></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Ryr2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4l4h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4l4h OCA], [http://pdbe.org/4l4h PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4l4h RCSB], [http://www.ebi.ac.uk/pdbsum/4l4h PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4l4h ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/RYR2_MOUSE RYR2_MOUSE]] Calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytoplasm and thereby plays a key role in triggering cardiac muscle contraction. Aberrant channel activation can lead to cardiac arrhythmia. In cardiac myocytes, calcium release is triggered by increased Ca(2+) levels due to activation of the L-type calcium channel CACNA1C. The calcium channel activity is modulated by formation of heterotetramers with RYR3. Required for cellular calcium ion homeostasis. Required for embryonic heart development.<ref>PMID:10473538</ref> <ref>PMID:9628868</ref> <ref>PMID:21098440</ref> <ref>PMID:20431056</ref>
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[https://www.uniprot.org/uniprot/RYR2_MOUSE RYR2_MOUSE] Calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytoplasm and thereby plays a key role in triggering cardiac muscle contraction. Aberrant channel activation can lead to cardiac arrhythmia. In cardiac myocytes, calcium release is triggered by increased Ca(2+) levels due to activation of the L-type calcium channel CACNA1C. The calcium channel activity is modulated by formation of heterotetramers with RYR3. Required for cellular calcium ion homeostasis. Required for embryonic heart development.<ref>PMID:10473538</ref> <ref>PMID:9628868</ref> <ref>PMID:21098440</ref> <ref>PMID:20431056</ref>
==See Also==
==See Also==
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*[[Ryanodine receptor|Ryanodine receptor]]
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*[[Ryanodine receptor 3D structures|Ryanodine receptor 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Lk3 transgenic mice]]
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[[Category: Large Structures]]
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[[Category: Kimlicka, L]]
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[[Category: Mus musculus]]
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[[Category: Petegem, F Van]]
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[[Category: Kimlicka L]]
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[[Category: Tung, C C]]
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[[Category: Tung CC]]
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[[Category: Ca2+ release]]
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[[Category: Van Petegem F]]
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[[Category: Er/sr membrane]]
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[[Category: Ion channel]]
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[[Category: Metal transport]]
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Revision as of 09:32, 7 December 2022

Crystal structure of mouse Ryanodine Receptor isoform 2 (RyR2) 1-547

PDB ID 4l4h

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