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Function of your protein

The specific function of ornithine aminotransferase is responsible for converting ornithine into pyrroline-5-carboxylate (P5C) to another molecule. Glutamate and proline are the amino acids that can be produced from P5C

Homo sapiens is the organism from which the HOAT is derived

These enzymes are comprised of two substrates, GABA and AVA

Biological relevance and broader implications

A type of cancer that is being studied is hepatocellular carcinoma, an aggressive form of liver cancer. Scientists have determined that HOAT is over-expressed in specific cells.

The study of the HOAT enzyme has enabled scientists to gain a more thorough understanding of metabolism. This is because it provides information about how the human body responds to specific stimuli through the use of this enzyme.

Important amino acids

are an important parts of the ligands binding site ^[3].

Hydrogen bonding - Val 143, Asp 263, Gly 142

Covalent bonding - Lys 292

Salt bridge - Asp 262 and Arg

Pi-stacking - Phe 177

Structural highlights

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An ornithine aminotransferase is composed of 50% of alpha helices, 45% of beta sheets, and 5% of other structures.

The beta sheet contains 1 of the 3 catalytic amino acids.