1jaw

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[[Image:1jaw.gif|left|200px]]
[[Image:1jaw.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1jaw |SIZE=350|CAPTION= <scene name='initialview01'>1jaw</scene>, resolution 2.7&Aring;
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The line below this paragraph, containing "STRUCTURE_1jaw", creates the "Structure Box" on the page.
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|SITE= <scene name='pdbsite=NUL:These+Residues+(Including+Acetate+-+Ace)+Coordinate+The+...'>NUL</scene>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Xaa-Pro_aminopeptidase Xaa-Pro aminopeptidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.11.9 3.4.11.9] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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-->
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|DOMAIN=
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{{STRUCTURE_1jaw| PDB=1jaw | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jaw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jaw OCA], [http://www.ebi.ac.uk/pdbsum/1jaw PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1jaw RCSB]</span>
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}}
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'''AMINOPEPTIDASE P FROM E. COLI LOW PH FORM'''
'''AMINOPEPTIDASE P FROM E. COLI LOW PH FORM'''
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[[Category: Lilley, P E.]]
[[Category: Lilley, P E.]]
[[Category: Wilce, M C.J.]]
[[Category: Wilce, M C.J.]]
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[[Category: aminopeptidase]]
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[[Category: Aminopeptidase]]
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[[Category: hydrolase]]
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[[Category: Hydrolase]]
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[[Category: proline peptidase]]
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[[Category: Proline peptidase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 20:59:47 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:30:59 2008''
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Revision as of 17:59, 2 May 2008

Image:1jaw.gif

Template:STRUCTURE 1jaw

AMINOPEPTIDASE P FROM E. COLI LOW PH FORM


Overview

The structure of the proline-specific aminopeptidase (EC 3.4.11.9) from Escherichia coli has been solved and refined for crystals of the native enzyme at a 2.0-A resolution, for a dipeptide-inhibited complex at 2.3-A resolution, and for a low-pH inactive form at 2.7-A resolution. The protein crystallizes as a tetramer, more correctly a dimer of dimers, at both high and low pH, consistent with observations from analytical ultracentrifuge studies that show that the protein is a tetramer under physiological conditions. The monomer folds into two domains. The active site, in the larger C-terminal domain, contains a dinuclear manganese center in which a bridging water molecule or hydroxide ion appears poised to act as the nucleophile in the attack on the scissile peptide bond of Xaa-Pro. The metal-binding residues are located in a single subunit, but the residues surrounding the active site are contributed by three subunits. The fold of the protein resembles that of creatine amidinohydrolase (creatinase, not a metalloenzyme). The C-terminal catalytic domain is also similar to the single-domain enzyme methionine aminopeptidase that has a dinuclear cobalt center.

About this Structure

1JAW is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Structure and mechanism of a proline-specific aminopeptidase from Escherichia coli., Wilce MC, Bond CS, Dixon NE, Freeman HC, Guss JM, Lilley PE, Wilce JA, Proc Natl Acad Sci U S A. 1998 Mar 31;95(7):3472-7. PMID:9520390 Page seeded by OCA on Fri May 2 20:59:47 2008

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OCA

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