Sandbox Reserved 1756

This is a default text for your page '. Click above on edit this page' to modify. Be careful with the < and > signs.

You may include any references to papers as in: the use of JSmol in Proteopedia ^[1] or to the article describing Jmol ^[2] to the rescue.

Function of your protein

The specific function of ornithine aminotransferase is responsible for converting ornithine into pyrroline-5-carboxylate (P5C) to another molecule. Glutamate and proline are the amino acids that can be produced from P5C

Homo sapiens is the organism from which the HOAT is derived

These enzymes are comprised of substrates - L-Orn, GABA and AVA. By using the soaking method, the GABA structure was covalently attached to the PLP, as well as the AVA structure. Both structures were covalently attached to both the PLP and Catalytic Lys292.

Biological relevance and broader implications

A type of cancer that is being studied is hepatocellular carcinoma, an aggressive form of liver cancer. Scientists have determined that HOAT is over-expressed in specific cells.

The study of the HOAT enzyme has enabled scientists to gain a more thorough understanding of metabolism. This is because it provides information about how the human body responds to specific stimuli through the use of this enzyme.

Important amino acids

are an important parts of the ligands binding site ^[3].

Hydrogen bonding - Val 143, Asp 263, Gly 142

Covalent bonding - Lys 292

Salt bridge - Asp 263 and Arg

Pi-stacking - Phe 177

Structural highlights

This is a sample scene created with SAT to by Group, and another to make of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.

Important to stabilize the protein

Each C=O consists of two oxygen atoms that form hydrogen bonds, which stabilize the secondary structure. A polar amino acid residue is on the outside and a nonpolar amino acid is inside the alpha helix since non-polar amino acids do not react with water. Beta sheet runs in an antiparallel direction of non-polar and polar amino acids.

represent of how much of molecules have occupied at the active site.

Other important features

plays a role important role in protein structure and ligand binding. Aromatic ring is important of protein interaction that allows pi stacking and acts as acceptor for hydrogen bonds. It is important for protein structure and ligand binding.

is important part of protein structure. It is found usually on the outside of the alpha and beta that is because of its water-loving quality. It help to determine the 3-D structure and its specifically function.