7t0q
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==human triosephosphate isomerase mutant v154m== | |
| - | + | <StructureSection load='7t0q' size='340' side='right'caption='[[7t0q]], [[Resolution|resolution]] 2.00Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[7t0q]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7T0Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7T0Q FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IPA:ISOPROPYL+ALCOHOL'>IPA</scene>, <scene name='pdbligand=PGA:2-PHOSPHOGLYCOLIC+ACID'>PGA</scene></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7t0q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7t0q OCA], [https://pdbe.org/7t0q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7t0q RCSB], [https://www.ebi.ac.uk/pdbsum/7t0q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7t0q ProSAT]</span></td></tr> |
| - | [[Category: Romero | + | </table> |
| + | == Disease == | ||
| + | [https://www.uniprot.org/uniprot/TPIS_HUMAN TPIS_HUMAN] Defects in TPI1 are the cause of triosephosphate isomerase deficiency (TPI deficiency) [MIM:[https://omim.org/entry/190450 190450]. TPI deficiency is an autosomal recessive disorder. It is the most severe clinical disorder of glycolysis. It is associated with neonatal jaundice, chronic hemolytic anemia, progressive neuromuscular dysfunction, cardiomyopathy and increased susceptibility to infection. | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/TPIS_HUMAN TPIS_HUMAN] | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Romero JM]] | ||
Revision as of 10:00, 14 December 2022
human triosephosphate isomerase mutant v154m
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