7xho

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'''Unreleased structure'''
 
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The entry 7xho is ON HOLD until Paper Publication
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==Structure of human inner kinetochore CCAN complex==
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<StructureSection load='7xho' size='340' side='right'caption='[[7xho]], [[Resolution|resolution]] 3.29&Aring;' scene=''>
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Authors: Tian, T., Wang, C.L., Yang, Z.S., Sun, L.F., Zang, J.Y.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[7xho]] is a 11 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7XHO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7XHO FirstGlance]. <br>
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Description: Structure of human inner kinetochore CCAN complex
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7xho FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7xho OCA], [https://pdbe.org/7xho PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7xho RCSB], [https://www.ebi.ac.uk/pdbsum/7xho PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7xho ProSAT]</span></td></tr>
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[[Category: Unreleased Structures]]
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</table>
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[[Category: Sun, L.F]]
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== Function ==
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[[Category: Wang, C.L]]
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[https://www.uniprot.org/uniprot/CENPC_HUMAN CENPC_HUMAN] Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. CENPC recruits DNA methylation and DNMT3B to both centromeric and pericentromeric satellite repeats and regulates the histone code in these regions.<ref>PMID:19482874</ref> <ref>PMID:21529714</ref>
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[[Category: Zang, J.Y]]
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== References ==
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[[Category: Tian, T]]
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<references/>
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[[Category: Yang, Z.S]]
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Sun LF]]
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[[Category: Tian T]]
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[[Category: Wang CL]]
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[[Category: Yang ZS]]
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[[Category: Zang JY]]

Revision as of 10:05, 14 December 2022

Structure of human inner kinetochore CCAN complex

PDB ID 7xho

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