7zr5
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==CryoEM structure of HSP90-CDC37-BRAF(V600E)-PP5(closed) complex== | |
| - | + | <StructureSection load='7zr5' size='340' side='right'caption='[[7zr5]], [[Resolution|resolution]] 3.90Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[7zr5]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7ZR5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7ZR5 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7zr5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7zr5 OCA], [https://pdbe.org/7zr5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7zr5 RCSB], [https://www.ebi.ac.uk/pdbsum/7zr5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7zr5 ProSAT]</span></td></tr> |
| - | [[Category: Oberoi | + | </table> |
| - | [[Category: Pearl | + | == Function == |
| + | [https://www.uniprot.org/uniprot/HS90B_HUMAN HS90B_HUMAN] Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.<ref>PMID:16478993</ref> <ref>PMID:19696785</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Oberoi J]] | ||
| + | [[Category: Pearl LH]] | ||
Revision as of 10:07, 14 December 2022
CryoEM structure of HSP90-CDC37-BRAF(V600E)-PP5(closed) complex
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