1jbq

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[[Image:1jbq.jpg|left|200px]]
[[Image:1jbq.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 1jbq |SIZE=350|CAPTION= <scene name='initialview01'>1jbq</scene>, resolution 2.60&Aring;
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The line below this paragraph, containing "STRUCTURE_1jbq", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=PLP:PYRIDOXAL-5&#39;-PHOSPHATE'>PLP</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Cystathionine_beta-synthase Cystathionine beta-synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.22 4.2.1.22] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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-->
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|DOMAIN=
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{{STRUCTURE_1jbq| PDB=1jbq | SCENE= }}
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|RELATEDENTRY=[[1d6s|1D6S]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jbq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jbq OCA], [http://www.ebi.ac.uk/pdbsum/1jbq PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1jbq RCSB]</span>
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}}
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'''STRUCTURE OF HUMAN CYSTATHIONINE BETA-SYNTHASE: A UNIQUE PYRIDOXAL 5'-PHOSPHATE DEPENDENT HEMEPROTEIN'''
'''STRUCTURE OF HUMAN CYSTATHIONINE BETA-SYNTHASE: A UNIQUE PYRIDOXAL 5'-PHOSPHATE DEPENDENT HEMEPROTEIN'''
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[[Category: Kraus, J P.]]
[[Category: Kraus, J P.]]
[[Category: Meier, M.]]
[[Category: Meier, M.]]
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[[Category: fold type ii of plp enzyme]]
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[[Category: Fold type ii of plp enzyme]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 21:01:37 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:31:21 2008''
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Revision as of 18:01, 2 May 2008

Image:1jbq.jpg

Template:STRUCTURE 1jbq

STRUCTURE OF HUMAN CYSTATHIONINE BETA-SYNTHASE: A UNIQUE PYRIDOXAL 5'-PHOSPHATE DEPENDENT HEMEPROTEIN


Overview

Cystathionine beta-synthase (CBS) is a unique heme- containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine. Deficiency of CBS leads to homocystinuria, an inherited disease of sulfur metabolism characterized by increased levels of the toxic metabolite homocysteine. Here we present the X-ray crystal structure of a truncated form of the enzyme. CBS shares the same fold with O-acetylserine sulfhydrylase but it contains an additional N-terminal heme binding site. This heme binding motif together with a spatially adjacent oxidoreductase active site motif could explain the regulation of its enzyme activity by redox changes.

About this Structure

1JBQ is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure of human cystathionine beta-synthase: a unique pyridoxal 5'-phosphate-dependent heme protein., Meier M, Janosik M, Kery V, Kraus JP, Burkhard P, EMBO J. 2001 Aug 1;20(15):3910-6. PMID:11483494 Page seeded by OCA on Fri May 2 21:01:37 2008

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