8b40
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Structure of homomeric LRRC8C Volume-Regulated Anion Channel== | |
| - | + | <StructureSection load='8b40' size='340' side='right'caption='[[8b40]], [[Resolution|resolution]] 4.60Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[8b40]] is a 7 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8B40 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8B40 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8b40 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8b40 OCA], [https://pdbe.org/8b40 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8b40 RCSB], [https://www.ebi.ac.uk/pdbsum/8b40 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8b40 ProSAT]</span></td></tr> | |
| - | [[Category: | + | </table> |
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/LRC8C_MOUSE LRC8C_MOUSE] Non-essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes (PubMed:29769723). The VRAC channel conducts iodide better than chloride and can also conduct organic osmolytes like taurine (By similarity). Plays a redundant role in the efflux of amino acids, such as aspartate and glutamate, in response to osmotic stress (By similarity). The VRAC channel also mediates transport of immunoreactive cyclic dinucleotide GMP-AMP (2'-3'-cGAMP), an immune messenger produced in response to DNA virus in the cytosol (By similarity). Channel activity requires LRRC8A plus at least one other family member (LRRC8B, LRRC8C, LRRC8D or LRRC8E); channel characteristics depend on the precise subunit composition (By similarity). May play a role in adipogenesis (PubMed:15184384, PubMed:15564382, PubMed:21804215).[UniProtKB:Q8TDW0]<ref>PMID:15184384</ref> <ref>PMID:15564382</ref> <ref>PMID:21804215</ref> <ref>PMID:29769723</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Mus musculus]] | ||
| + | [[Category: Dutzler R]] | ||
| + | [[Category: Sawicka M]] | ||
Revision as of 10:08, 14 December 2022
Structure of homomeric LRRC8C Volume-Regulated Anion Channel
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