8f7s

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m (Protected "8f7s" [edit=sysop:move=sysop])
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'''Unreleased structure'''
 
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The entry 8f7s is ON HOLD
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==Gi bound delta-opioid receptor in complex with deltorphin==
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<StructureSection load='8f7s' size='340' side='right'caption='[[8f7s]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
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Authors: Wang, Y., Zhuang, Y., DiBerto, J.F., Zhou, X.E., Schmitz, G.P., Yuan, Q., Jain, M.K., Liu, W., Melcher, K., Jiang, Y., Roth, B.L., Xu, H.E.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[8f7s]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus], [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens], [https://en.wikipedia.org/wiki/Phyllomedusa Phyllomedusa] and [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8F7S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8F7S FirstGlance]. <br>
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Description: Gi bound delta-opioid receptor in complex with deltorphin
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CLR:CHOLESTEROL'>CLR</scene>, <scene name='pdbligand=DAL:D-ALANINE'>DAL</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene>, <scene name='pdbligand=PLM:PALMITIC+ACID'>PLM</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8f7s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8f7s OCA], [https://pdbe.org/8f7s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8f7s RCSB], [https://www.ebi.ac.uk/pdbsum/8f7s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8f7s ProSAT]</span></td></tr>
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[[Category: Zhou, X.E]]
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</table>
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[[Category: Xu, H.E]]
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== Function ==
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[[Category: Jain, M.K]]
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[https://www.uniprot.org/uniprot/OPRD_HUMAN OPRD_HUMAN] G-protein coupled receptor that functions as receptor for endogenous enkephalins and for a subset of other opioids. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain and in opiate-mediated analgesia. Plays a role in developing analgesic tolerance to morphine.<ref>PMID:22184124</ref> <ref>PMID:7808419</ref> <ref>PMID:8201839</ref>
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[[Category: Melcher, K]]
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== References ==
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[[Category: Liu, W]]
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<references/>
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[[Category: Diberto, J.F]]
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__TOC__
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[[Category: Jiang, Y]]
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</StructureSection>
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[[Category: Wang, Y]]
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[[Category: Bos taurus]]
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[[Category: Zhuang, Y]]
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[[Category: Homo sapiens]]
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[[Category: Roth, B.L]]
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[[Category: Large Structures]]
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[[Category: Yuan, Q]]
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[[Category: Phyllomedusa]]
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[[Category: Schmitz, G.P]]
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[[Category: Rattus norvegicus]]
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[[Category: DiBerto JF]]
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[[Category: Jain MK]]
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[[Category: Jiang Y]]
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[[Category: Liu W]]
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[[Category: Melcher K]]
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[[Category: Roth BL]]
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[[Category: Schmitz GP]]
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[[Category: Wang Y]]
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[[Category: Xu HE]]
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[[Category: Yuan Q]]
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[[Category: Zhou XE]]
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[[Category: Zhuang Y]]

Revision as of 10:12, 14 December 2022

Gi bound delta-opioid receptor in complex with deltorphin

PDB ID 8f7s

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