4fhi

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<StructureSection load='4fhi' size='340' side='right'caption='[[4fhi]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
<StructureSection load='4fhi' size='340' side='right'caption='[[4fhi]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4fhi]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Brachidanio_rerio Brachidanio rerio]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FHI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4FHI FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4fhi]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Danio_rerio Danio rerio] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FHI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4FHI FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0S4:N-HYDROXY-2-{4-[3-(4-{[(2R)-2-HYDROXY-3,3-DIMETHYLBUTYL]OXY}-3-METHYLPHENYL)PENTAN-3-YL]-2-METHYLPHENOXY}ACETAMIDE'>0S4</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0S4:N-HYDROXY-2-{4-[3-(4-{[(2R)-2-HYDROXY-3,3-DIMETHYLBUTYL]OXY}-3-METHYLPHENYL)PENTAN-3-YL]-2-METHYLPHENOXY}ACETAMIDE'>0S4</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[4fhh|4fhh]]</div></td></tr>
 
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4fhi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fhi OCA], [https://pdbe.org/4fhi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4fhi RCSB], [https://www.ebi.ac.uk/pdbsum/4fhi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4fhi ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4fhi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4fhi OCA], [https://pdbe.org/4fhi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4fhi RCSB], [https://www.ebi.ac.uk/pdbsum/4fhi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4fhi ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/VDRA_DANRE VDRA_DANRE] Nuclear hormone receptor. Transcription factor that mediates the action of vitamin D3 by controlling the expression of hormone sensitive genes. Regulates transcription of hormone sensitive genes via its association with the WINAC complex, a chromatin-remodeling complex. Plays a central role in calcium homeostasis.<ref>PMID:17218092</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Brachidanio rerio]]
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[[Category: Danio rerio]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Fischer, J]]
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[[Category: Fischer J]]
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[[Category: Gleason, J L]]
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[[Category: Gleason JL]]
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[[Category: Kaldre, D]]
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[[Category: Kaldre D]]
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[[Category: Moras, D]]
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[[Category: Moras D]]
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[[Category: Rochel, N]]
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[[Category: Rochel N]]
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[[Category: Wang, T T]]
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[[Category: Wang TT]]
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[[Category: White, J H]]
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[[Category: White JH]]
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[[Category: Alpha helical sandwich]]
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[[Category: Dna coregulator]]
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[[Category: Ligand binding domain alpha helical sandwich]]
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[[Category: Nucleus]]
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[[Category: Phosphorylation]]
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[[Category: Transcription factor]]
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[[Category: Transcription-protein binding-inhibitor complex]]
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Revision as of 10:40, 14 December 2022

Development of synthetically accessible non-secosteroidal hybrid molecules combining vitamin D receptor agonism and histone deacetylase inhibition

PDB ID 4fhi

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