4lc9

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
==Structural Basis for Regulation of Human Glucokinase by Glucokinase Regulatory Protein==
==Structural Basis for Regulation of Human Glucokinase by Glucokinase Regulatory Protein==
-
<StructureSection load='4lc9' size='340' side='right' caption='[[4lc9]], [[Resolution|resolution]] 3.40&Aring;' scene=''>
+
<StructureSection load='4lc9' size='340' side='right'caption='[[4lc9]], [[Resolution|resolution]] 3.40&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[4lc9]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat] and [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LC9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4LC9 FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[4lc9]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LC9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4LC9 FirstGlance]. <br>
-
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=F6P:FRUCTOSE-6-PHOSPHATE'>F6P</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
+
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=F6P:FRUCTOSE-6-PHOSPHATE'>F6P</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
-
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1v4t|1v4t]], [[1v4s|1v4s]]</td></tr>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4lc9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4lc9 OCA], [https://pdbe.org/4lc9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4lc9 RCSB], [https://www.ebi.ac.uk/pdbsum/4lc9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4lc9 ProSAT]</span></td></tr>
-
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Gckr ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat]), GCK ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
+
-
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span></td></tr>
+
-
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4lc9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4lc9 OCA], [http://pdbe.org/4lc9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4lc9 RCSB], [http://www.ebi.ac.uk/pdbsum/4lc9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4lc9 ProSAT]</span></td></tr>
+
</table>
</table>
-
== Disease ==
 
-
[[http://www.uniprot.org/uniprot/HXK4_HUMAN HXK4_HUMAN]] Defects in GCK are the cause of maturity-onset diabetes of the young type 2 (MODY2) [MIM:[http://omim.org/entry/125851 125851]]; also shortened MODY-2. MODY is a form of diabetes that is characterized by an autosomal dominant mode of inheritance, onset in childhood or early adulthood (usually before 25 years of age), a primary defect in insulin secretion and frequent insulin-independence at the beginning of the disease.<ref>PMID:1502186</ref> <ref>PMID:1464666</ref> <ref>PMID:1303265</ref> <ref>PMID:8495817</ref> <ref>PMID:8325892</ref> <ref>PMID:8446612</ref> <ref>PMID:8168652</ref> <ref>PMID:9049484</ref> <ref>PMID:10694920</ref> <ref>PMID:9662401</ref> <ref>PMID:10588527</ref> <ref>PMID:11106831</ref> <ref>PMID:11372010</ref> Defects in GCK are the cause of familial hyperinsulinemic hypoglycemia type 3 (HHF3) [MIM:[http://omim.org/entry/602485 602485]]; also known as persistent hyperinsulinemic hypoglycemia of infancy (PHHI) or congenital hyperinsulinism. HHF is the most common cause of persistent hypoglycemia in infancy. Unless early and aggressive intervention is undertaken, brain damage from recurrent episodes of hypoglycemia may occur.<ref>PMID:9435328</ref>
 
== Function ==
== Function ==
-
[[http://www.uniprot.org/uniprot/GCKR_RAT GCKR_RAT]] Inhibits glucokinase by forming an inactive complex with this enzyme. [[http://www.uniprot.org/uniprot/HXK4_HUMAN HXK4_HUMAN]] Catalyzes the initial step in utilization of glucose by the beta-cell and liver at physiological glucose concentration. Glucokinase has a high Km for glucose, and so it is effective only when glucose is abundant. The role of GCK is to provide G6P for the synthesis of glycogen. Pancreatic glucokinase plays an important role in modulating insulin secretion. Hepatic glucokinase helps to facilitate the uptake and conversion of glucose by acting as an insulin-sensitive determinant of hepatic glucose usage.
+
[https://www.uniprot.org/uniprot/GCKR_RAT GCKR_RAT] Inhibits glucokinase by forming an inactive complex with this enzyme.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
Line 23: Line 18:
</div>
</div>
<div class="pdbe-citations 4lc9" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 4lc9" style="background-color:#fffaf0;"></div>
 +
 +
==See Also==
 +
*[[Glucokinase Regulatory Protein|Glucokinase Regulatory Protein]]
 +
*[[Hexokinase 3D structures|Hexokinase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
-
[[Category: Buffalo rat]]
+
[[Category: Homo sapiens]]
-
[[Category: Glucokinase]]
+
[[Category: Large Structures]]
-
[[Category: Human]]
+
[[Category: Rattus norvegicus]]
-
[[Category: Beck, T]]
+
[[Category: Beck T]]
-
[[Category: Miller, B G]]
+
[[Category: Miller BG]]
-
[[Category: Transferase-transferase regulator complex]]
+
-
[[Category: Type 2 diabetes]]
+

Revision as of 10:51, 14 December 2022

Structural Basis for Regulation of Human Glucokinase by Glucokinase Regulatory Protein

PDB ID 4lc9

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4lc9"
Personal tools