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4lcu

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Current revision (10:52, 14 December 2022) (edit) (undo)
 
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==Structure of KcsA with E118A mutation==
==Structure of KcsA with E118A mutation==
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<StructureSection load='4lcu' size='340' side='right' caption='[[4lcu]], [[Resolution|resolution]] 2.75&Aring;' scene=''>
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<StructureSection load='4lcu' size='340' side='right'caption='[[4lcu]], [[Resolution|resolution]] 2.75&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4lcu]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/"actinomyces_lividans"_krasil'nikov_et_al._1965 "actinomyces lividans" krasil'nikov et al. 1965] and [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LCU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4LCU FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4lcu]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [https://en.wikipedia.org/wiki/Streptomyces_lividans Streptomyces lividans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LCU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4LCU FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DGA:DIACYL+GLYCEROL'>DGA</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DGA:DIACYL+GLYCEROL'>DGA</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4lbe|4lbe]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4lcu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4lcu OCA], [https://pdbe.org/4lcu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4lcu RCSB], [https://www.ebi.ac.uk/pdbsum/4lcu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4lcu ProSAT]</span></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">kcsA, skc1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1916 "Actinomyces lividans" Krasil'nikov et al. 1965])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4lcu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4lcu OCA], [http://pdbe.org/4lcu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4lcu RCSB], [http://www.ebi.ac.uk/pdbsum/4lcu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4lcu ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/KCSA_STRLI KCSA_STRLI]] Acts as a pH-gated potassium ion channel; changing the cytosolic pH from 7 to 4 opens the channel, although it is not clear if this is the physiological stimulus for channel opening. Monovalent cation preference is K(+) > Rb(+) > NH4(+) >> Na(+) > Li(+).<ref>PMID:7489706</ref>
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[https://www.uniprot.org/uniprot/KCSA_STRLI KCSA_STRLI] Acts as a pH-gated potassium ion channel; changing the cytosolic pH from 7 to 4 opens the channel, although it is not clear if this is the physiological stimulus for channel opening. Monovalent cation preference is K(+) > Rb(+) > NH4(+) >> Na(+) > Li(+).<ref>PMID:7489706</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 4lcu" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 4lcu" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Potassium channel 3D structures|Potassium channel 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Actinomyces lividans krasil'nikov et al. 1965]]
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[[Category: Large Structures]]
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[[Category: Lk3 transgenic mice]]
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[[Category: Mus musculus]]
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[[Category: McCoy, J M]]
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[[Category: Streptomyces lividans]]
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[[Category: Nimigean, C M]]
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[[Category: McCoy JM]]
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[[Category: Posson, D J]]
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[[Category: Nimigean CM]]
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[[Category: Membrane protein]]
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[[Category: Posson DJ]]
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[[Category: Ph-gated potassium channel]]
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[[Category: Potassium channel]]
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[[Category: Transport protein]]
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[[Category: Voltage gated potassium channel]]
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Current revision

Structure of KcsA with E118A mutation

PDB ID 4lcu

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