4lg9

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<StructureSection load='4lg9' size='340' side='right'caption='[[4lg9]], [[Resolution|resolution]] 2.28&Aring;' scene=''>
<StructureSection load='4lg9' size='340' side='right'caption='[[4lg9]], [[Resolution|resolution]] 2.28&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4lg9]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LG9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4LG9 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4lg9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LG9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4LG9 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">TBL1XR1, IRA1, TBLR1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4lg9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4lg9 OCA], [https://pdbe.org/4lg9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4lg9 RCSB], [https://www.ebi.ac.uk/pdbsum/4lg9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4lg9 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4lg9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4lg9 OCA], [http://pdbe.org/4lg9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4lg9 RCSB], [http://www.ebi.ac.uk/pdbsum/4lg9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4lg9 ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/TBL1R_HUMAN TBL1R_HUMAN]] F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units. Plays an essential role in transcription activation mediated by nuclear receptors. Probably acts as integral component of the N-Cor corepressor complex that mediates the recruitment of the 19S proteasome complex, leading to the subsequent proteasomal degradation of N-Cor complex, thereby allowing cofactor exchange, and transcription activation.<ref>PMID:14980219</ref>
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[https://www.uniprot.org/uniprot/TBL1R_HUMAN TBL1R_HUMAN] F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units. Plays an essential role in transcription activation mediated by nuclear receptors. Probably acts as integral component of the N-Cor corepressor complex that mediates the recruitment of the 19S proteasome complex, leading to the subsequent proteasomal degradation of N-Cor complex, thereby allowing cofactor exchange, and transcription activation.<ref>PMID:14980219</ref>
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Arrowsmith, C H]]
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[[Category: Arrowsmith CH]]
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[[Category: Bountra, C]]
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[[Category: Bountra C]]
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[[Category: Edwards, A M]]
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[[Category: Edwards AM]]
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[[Category: He, H]]
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[[Category: He H]]
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[[Category: Min, J]]
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[[Category: Min J]]
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[[Category: Structural genomic]]
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[[Category: Seitova A]]
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[[Category: Seitova, A]]
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[[Category: Tempel W]]
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[[Category: Tempel, W]]
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[[Category: Wu X]]
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[[Category: Wu, X]]
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[[Category: Xu C]]
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[[Category: Xu, C]]
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[[Category: Sgc]]
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[[Category: Unknown function]]
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[[Category: Wd40 repeat]]
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Revision as of 10:59, 14 December 2022

Crystal structure of TBL1XR1 WD40 repeats

PDB ID 4lg9

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OCA

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