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4lhv

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==Crystal structure of Rab8 in its inactive GDP-bound form==
==Crystal structure of Rab8 in its inactive GDP-bound form==
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<StructureSection load='4lhv' size='340' side='right' caption='[[4lhv]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
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<StructureSection load='4lhv' size='340' side='right'caption='[[4lhv]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4lhv]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LHV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4LHV FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4lhv]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LHV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4LHV FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4lhw|4lhw]], [[4lhx|4lhx]], [[4lhy|4lhy]], [[4lhz|4lhz]], [[4li0|4li0]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4lhv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4lhv OCA], [https://pdbe.org/4lhv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4lhv RCSB], [https://www.ebi.ac.uk/pdbsum/4lhv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4lhv ProSAT]</span></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">RAB8A, MEL, RAB8 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4lhv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4lhv OCA], [http://pdbe.org/4lhv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4lhv RCSB], [http://www.ebi.ac.uk/pdbsum/4lhv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4lhv ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/RAB8A_HUMAN RAB8A_HUMAN]] May be involved in vesicular trafficking and neurotransmitter release. Together with RAB11A, RAB3IP, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis. Together with MYO5B and RAB11A participates in epithelial cell polarization.<ref>PMID:20890297</ref> <ref>PMID:21282656</ref>
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[https://www.uniprot.org/uniprot/RAB8A_HUMAN RAB8A_HUMAN] May be involved in vesicular trafficking and neurotransmitter release. Together with RAB11A, RAB3IP, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis. Together with MYO5B and RAB11A participates in epithelial cell polarization.<ref>PMID:20890297</ref> <ref>PMID:21282656</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 4lhv" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 4lhv" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Ras-related protein Rab 3D structures|Ras-related protein Rab 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
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[[Category: Goody, R S]]
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[[Category: Large Structures]]
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[[Category: Guo, Z]]
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[[Category: Goody RS]]
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[[Category: Hou, X M]]
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[[Category: Guo Z]]
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[[Category: Itzen, A]]
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[[Category: Hou XM]]
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[[Category: Protein transport]]
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[[Category: Itzen A]]
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[[Category: Small gtpase]]
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Revision as of 11:02, 14 December 2022

Crystal structure of Rab8 in its inactive GDP-bound form

PDB ID 4lhv

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