4lk6

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==Crystal Structure of Pseudomonas aeruginosa Lectin LecA Complexed with Chlorophenol Red-b-D-galactopyranoside at 2.86 A Resolution==
==Crystal Structure of Pseudomonas aeruginosa Lectin LecA Complexed with Chlorophenol Red-b-D-galactopyranoside at 2.86 A Resolution==
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<StructureSection load='4lk6' size='340' side='right' caption='[[4lk6]], [[Resolution|resolution]] 2.86&Aring;' scene=''>
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<StructureSection load='4lk6' size='340' side='right'caption='[[4lk6]], [[Resolution|resolution]] 2.86&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4lk6]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Pseae Pseae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LK6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4LK6 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4lk6]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_aeruginosa_PAO1 Pseudomonas aeruginosa PAO1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LK6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4LK6 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=LRD:2-[(E)-(3-CHLORO-4-HYDROXYPHENYL)(3-CHLORO-4-OXOCYCLOHEXA-2,5-DIEN-1-YLIDENE)METHYL]BENZENESULFONIC+ACID'>LRD</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=LRD:2-[(E)-(3-CHLORO-4-HYDROXYPHENYL)(3-CHLORO-4-OXOCYCLOHEXA-2,5-DIEN-1-YLIDENE)METHYL]BENZENESULFONIC+ACID'>LRD</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4ljh|4ljh]], [[4lk7|4lk7]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4lk6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4lk6 OCA], [https://pdbe.org/4lk6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4lk6 RCSB], [https://www.ebi.ac.uk/pdbsum/4lk6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4lk6 ProSAT]</span></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">lecA, pa1L, PA2570 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=208964 PSEAE])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4lk6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4lk6 OCA], [http://pdbe.org/4lk6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4lk6 RCSB], [http://www.ebi.ac.uk/pdbsum/4lk6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4lk6 ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/PA1L_PSEAE PA1L_PSEAE]] D-galactose specific lectin. Binds in decreasing order of affinity: melibiose, methyl-alpha-D-galactoside, D-galactose, methyl-beta-D-galactoside, N-acetyl-D-galactosamine. Similar to plant lectins in its selective (carbohydrate-specific) hemagglutinating activity.
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[https://www.uniprot.org/uniprot/PA1L_PSEAE PA1L_PSEAE] D-galactose specific lectin. Binds in decreasing order of affinity: melibiose, methyl-alpha-D-galactoside, D-galactose, methyl-beta-D-galactoside, N-acetyl-D-galactosamine. Similar to plant lectins in its selective (carbohydrate-specific) hemagglutinating activity.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Pseae]]
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[[Category: Large Structures]]
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[[Category: Kadam, R U]]
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[[Category: Pseudomonas aeruginosa PAO1]]
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[[Category: Reymond, J L]]
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[[Category: Kadam RU]]
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[[Category: Stocker, A]]
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[[Category: Reymond JL]]
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[[Category: Galactose]]
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[[Category: Stocker A]]
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[[Category: Lectin fold]]
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[[Category: Sugar binding protein]]
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Revision as of 11:05, 14 December 2022

Crystal Structure of Pseudomonas aeruginosa Lectin LecA Complexed with Chlorophenol Red-b-D-galactopyranoside at 2.86 A Resolution

PDB ID 4lk6

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