4lry

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==Crystal Structure of the E.coli DhaR(N)-DhaK(T79L) complex==
==Crystal Structure of the E.coli DhaR(N)-DhaK(T79L) complex==
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<StructureSection load='4lry' size='340' side='right' caption='[[4lry]], [[Resolution|resolution]] 2.83&Aring;' scene=''>
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<StructureSection load='4lry' size='340' side='right'caption='[[4lry]], [[Resolution|resolution]] 2.83&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4lry]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Ecoli Ecoli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LRY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4LRY FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4lry]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LRY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4LRY FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4lrx|4lrx]], [[4lrz|4lrz]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4lry FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4lry OCA], [https://pdbe.org/4lry PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4lry RCSB], [https://www.ebi.ac.uk/pdbsum/4lry PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4lry ProSAT]</span></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">b1200, dhaK, dhaR, JW5187, ycgT ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 ECOLI]), b1201, dhaK, dhaR, JW5188, ycgU ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 ECOLI])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4lry FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4lry OCA], [http://pdbe.org/4lry PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4lry RCSB], [http://www.ebi.ac.uk/pdbsum/4lry PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4lry ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/DHAK_ECOLI DHAK_ECOLI]] Dihydroxyacetone binding subunit of the dihydroxyacetone kinase, which is responsible for phosphorylating dihydroxyacetone. Binds covalently dihydroxyacetone in hemiaminal linkage. Acts also as a corepressor of DhaR by binding to its sensor domain, in the absence of dihydroxyacetone. [[http://www.uniprot.org/uniprot/DHAR_ECOLI DHAR_ECOLI]] Positively regulates the dhaKLM operon from a sigma-70 promoter. Represses its own synthesis.
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[https://www.uniprot.org/uniprot/DHAK_ECOLI DHAK_ECOLI] Dihydroxyacetone binding subunit of the dihydroxyacetone kinase, which is responsible for phosphorylating dihydroxyacetone. Binds covalently dihydroxyacetone in hemiaminal linkage. Acts also as a corepressor of DhaR by binding to its sensor domain, in the absence of dihydroxyacetone.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Ecoli]]
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[[Category: Escherichia coli K-12]]
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[[Category: Cygler, M]]
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[[Category: Large Structures]]
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[[Category: Ekiel, I]]
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[[Category: Cygler M]]
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[[Category: McDonald, L]]
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[[Category: Ekiel I]]
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[[Category: Shi, R]]
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[[Category: McDonald L]]
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[[Category: Coiled-coil]]
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[[Category: Shi R]]
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[[Category: Gaf]]
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[[Category: Helix rotation]]
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[[Category: Pa]]
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[[Category: Transcriptional regulation complex]]
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[[Category: Transferase-transcription regulator complex]]
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Revision as of 11:23, 14 December 2022

Crystal Structure of the E.coli DhaR(N)-DhaK(T79L) complex

PDB ID 4lry

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