1jdn

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
[[Image:1jdn.gif|left|200px]]
[[Image:1jdn.gif|left|200px]]
-
{{Structure
+
<!--
-
|PDB= 1jdn |SIZE=350|CAPTION= <scene name='initialview01'>1jdn</scene>, resolution 2.9&Aring;
+
The line below this paragraph, containing "STRUCTURE_1jdn", creates the "Structure Box" on the page.
-
|SITE=
+
You may change the PDB parameter (which sets the PDB file loaded into the applet)
-
|LIGAND= <scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NDG:2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE'>NDG</scene>
+
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-
|ACTIVITY=
+
or leave the SCENE parameter empty for the default display.
-
|GENE=
+
-->
-
|DOMAIN=
+
{{STRUCTURE_1jdn| PDB=1jdn | SCENE= }}
-
|RELATEDENTRY=[[1jdp|1JDP]]
+
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jdn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jdn OCA], [http://www.ebi.ac.uk/pdbsum/1jdn PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1jdn RCSB]</span>
+
-
}}
+
'''Crystal Structure of Hormone Receptor'''
'''Crystal Structure of Hormone Receptor'''
Line 29: Line 26:
[[Category: He, X L.]]
[[Category: He, X L.]]
[[Category: Martick, M M.]]
[[Category: Martick, M M.]]
-
[[Category: allosteric activation]]
+
[[Category: Allosteric activation]]
-
[[Category: crystal structure]]
+
[[Category: Crystal structure]]
-
[[Category: dimer]]
+
[[Category: Dimer]]
-
[[Category: natriuretic peptide receptor]]
+
[[Category: Natriuretic peptide receptor]]
-
 
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 21:05:54 2008''
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:32:07 2008''
+

Revision as of 18:05, 2 May 2008

Image:1jdn.gif

Template:STRUCTURE 1jdn

Crystal Structure of Hormone Receptor


Overview

Natriuretic peptides (NPs) are vasoactive cyclic-peptide hormones important in blood pressure regulation through interaction with natriuretic cell-surface receptors. We report the hormone-binding thermodynamics and crystal structures at 2.9 and 2.0 angstroms, respectively, of the extracellular domain of the unliganded human NP receptor (NPR-C) and its complex with CNP, a 22-amino acid NP. A single CNP molecule is bound in the interface of an NPR-C dimer, resulting in asymmetric interactions between the hormone and the symmetrically related receptors. Hormone binding induces a 20 angstrom closure between the membrane-proximal domains of the dimer. In each monomer, the opening of an interdomain cleft, which is tethered together by a linker peptide acting as a molecular spring, is likely a conserved allosteric trigger for intracellular signaling by the natriuretic receptor family.

About this Structure

1JDN is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Allosteric activation of a spring-loaded natriuretic peptide receptor dimer by hormone., He Xl, Chow Dc, Martick MM, Garcia KC, Science. 2001 Aug 31;293(5535):1657-62. PMID:11533490 Page seeded by OCA on Fri May 2 21:05:54 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1jdn"
Personal tools