8bw4
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==PanDDA analysis -- Crystal Structure of PHIP in complex with Z198194396 synthetic derivative== | |
| - | + | <StructureSection load='8bw4' size='340' side='right'caption='[[8bw4]], [[Resolution|resolution]] 1.55Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[8bw4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=5s9i 5s9i]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8BW4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8BW4 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=Y3S:(2R)-4-(3-fluoranylthiophen-2-yl)carbonyl-N-(4-methoxyphenyl)-2-methyl-piperazine-1-carboxamide'>Y3S</scene></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8bw4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8bw4 OCA], [https://pdbe.org/8bw4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8bw4 RCSB], [https://www.ebi.ac.uk/pdbsum/8bw4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8bw4 ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/PHIP_HUMAN PHIP_HUMAN] Probable regulator of the insulin and insulin-like growth factor signaling pathways. Stimulates cell proliferation through regulation of cyclin transcription and has an anti-apoptotic activity through AKT1 phosphorylation and activation. Plays a role in the regulation of cell morphology and cytoskeletal organization.<ref>PMID:12242307</ref> <ref>PMID:21834987</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Aimon A]] | ||
| + | [[Category: Biggin PC]] | ||
| + | [[Category: Bradshaw WJ]] | ||
| + | [[Category: Douangamath A]] | ||
| + | [[Category: Grosjean H]] | ||
| + | [[Category: Hassell-Hart S]] | ||
| + | [[Category: Koekemoer L]] | ||
| + | [[Category: Krojer T]] | ||
| + | [[Category: Spencer J]] | ||
| + | [[Category: Talon R]] | ||
| + | [[Category: Von Delft F]] | ||
Revision as of 09:17, 21 December 2022
PanDDA analysis -- Crystal Structure of PHIP in complex with Z198194396 synthetic derivative
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Categories: Homo sapiens | Large Structures | Aimon A | Biggin PC | Bradshaw WJ | Douangamath A | Grosjean H | Hassell-Hart S | Koekemoer L | Krojer T | Spencer J | Talon R | Von Delft F
