8blv
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | The | + | ==The PDZ domains of human SDCBP with a bound SDC4 C-terminal peptide== |
| - | + | <StructureSection load='8blv' size='340' side='right'caption='[[8blv]], [[Resolution|resolution]] 1.50Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[8blv]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8BLV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8BLV FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8blv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8blv OCA], [https://pdbe.org/8blv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8blv RCSB], [https://www.ebi.ac.uk/pdbsum/8blv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8blv ProSAT]</span></td></tr> |
| - | [[Category: | + | </table> |
| - | [[Category: | + | == Function == |
| - | [[Category: Brennan | + | [https://www.uniprot.org/uniprot/SDCB1_HUMAN SDCB1_HUMAN] Seems to function as an adapter protein. In adherens junctions may function to couple syndecans to cytoskeletal proteins or signaling components. Seems to couple transcription factor SOX4 to the IL-5 receptor (IL5RA). May also play a role in vesicular trafficking. Seems to be required for the targeting of TGFA to the cell surface in the early secretory pathway.<ref>PMID:10230395</ref> <ref>PMID:11179419</ref> <ref>PMID:11498591</ref> |
| - | [[Category: | + | == References == |
| - | [[Category: | + | <references/> |
| - | [[Category: | + | __TOC__ |
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Bountra C]] | ||
| + | [[Category: Bradshaw WJ]] | ||
| + | [[Category: Brennan PE]] | ||
| + | [[Category: Daniel-Mozo M]] | ||
| + | [[Category: Katis VL]] | ||
| + | [[Category: Von Delft F]] | ||
Revision as of 09:28, 21 December 2022
The PDZ domains of human SDCBP with a bound SDC4 C-terminal peptide
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