8hg1
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | The | + | ==The structure of MPXV polymerase holoenzyme in replicating state== |
| - | + | <StructureSection load='8hg1' size='340' side='right'caption='[[8hg1]], [[Resolution|resolution]] 2.80Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[8hg1]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Monkeypox_virus Monkeypox virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8HG1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8HG1 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=TTP:THYMIDINE-5-TRIPHOSPHATE'>TTP</scene></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8hg1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8hg1 OCA], [https://pdbe.org/8hg1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8hg1 RCSB], [https://www.ebi.ac.uk/pdbsum/8hg1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8hg1 ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/Q5IXS4_MONPV Q5IXS4_MONPV] Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine. Also part of a heterodimeric processivity factor which potentiates the DNA polymerase activity. Binds to DNA.[ARBA:ARBA00025092] | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Monkeypox virus]] | ||
| + | [[Category: Gao F]] | ||
| + | [[Category: Kuai L]] | ||
| + | [[Category: Peng Q]] | ||
| + | [[Category: Qi JX]] | ||
| + | [[Category: Shi Y]] | ||
| + | [[Category: Wang H]] | ||
| + | [[Category: Xie YF]] | ||
Revision as of 09:31, 21 December 2022
The structure of MPXV polymerase holoenzyme in replicating state
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Categories: Large Structures | Monkeypox virus | Gao F | Kuai L | Peng Q | Qi JX | Shi Y | Wang H | Xie YF
