1ca1

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<StructureSection load='1ca1' size='340' side='right'caption='[[1ca1]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
<StructureSection load='1ca1' size='340' side='right'caption='[[1ca1]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1ca1]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CA1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1CA1 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1ca1]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Clostridium_perfringens Clostridium perfringens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CA1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1CA1 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Phospholipase_C Phospholipase C], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.4.3 3.1.4.3] </span></td></tr>
 
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ca1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ca1 OCA], [https://pdbe.org/1ca1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ca1 RCSB], [https://www.ebi.ac.uk/pdbsum/1ca1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ca1 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ca1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ca1 OCA], [https://pdbe.org/1ca1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ca1 RCSB], [https://www.ebi.ac.uk/pdbsum/1ca1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ca1 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/PHLC1_CLOPE PHLC1_CLOPE]] Bacterial hemolysins are exotoxins that attack blood cell membranes and cause cell rupture. Constitutes an essential virulence factor in gas gangrene. Binds to eukaryotic membranes where it hydrolyzes both phosphatidylcholine and sphingomyelin. The diacylglycerol produced can activate both the arachidonic acid pathway, leading to modulation of the inflammatory response cascade and thrombosis, and protein kinase C, leading to activation of eukaryotic phospholipases and further membrane damage. Acts on human and mouse erythrocytes, but not on rabbit or horse erythrocytes.
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[https://www.uniprot.org/uniprot/PHLC1_CLOPE PHLC1_CLOPE] Bacterial hemolysins are exotoxins that attack blood cell membranes and cause cell rupture. Constitutes an essential virulence factor in gas gangrene. Binds to eukaryotic membranes where it hydrolyzes both phosphatidylcholine and sphingomyelin. The diacylglycerol produced can activate both the arachidonic acid pathway, leading to modulation of the inflammatory response cascade and thrombosis, and protein kinase C, leading to activation of eukaryotic phospholipases and further membrane damage. Acts on human and mouse erythrocytes, but not on rabbit or horse erythrocytes.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Clostridium perfringens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Phospholipase C]]
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[[Category: Basak AK]]
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[[Category: Basak, A K]]
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[[Category: Naylor CE]]
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[[Category: Naylor, C E]]
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[[Category: Titball RW]]
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[[Category: Titball, R W]]
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[[Category: C2 domain]]
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[[Category: Ca and membrane binding]]
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[[Category: Gangrene determinant]]
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[[Category: Hydrolase]]
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[[Category: Zinc phospholipase c]]
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Revision as of 09:33, 21 December 2022

ALPHA-TOXIN FROM CLOSTRIDIUM PERFRINGENS

PDB ID 1ca1

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