1fim

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Current revision (09:38, 21 December 2022) (edit) (undo)
 
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<StructureSection load='1fim' size='340' side='right'caption='[[1fim]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
<StructureSection load='1fim' size='340' side='right'caption='[[1fim]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1fim]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FIM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1FIM FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1fim]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FIM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1FIM FirstGlance]. <br>
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</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1fim FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fim OCA], [https://pdbe.org/1fim PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1fim RCSB], [https://www.ebi.ac.uk/pdbsum/1fim PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1fim ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1fim FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fim OCA], [https://pdbe.org/1fim PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1fim RCSB], [https://www.ebi.ac.uk/pdbsum/1fim PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1fim ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/MIF_RAT MIF_RAT]] Pro-inflammatory cytokine. Involved in the innate immune response to bacterial pathogens. The expression of MIF at sites of inflammation suggests a role as mediator in regulating the function of macrophages in host defense. Counteracts the anti-inflammatory activity of glucocorticoids. Has phenylpyruvate tautomerase and dopachrome tautomerase activity (in vitro), but the physiological substrate is not known. It is not clear whether the tautomerase activity has any physiological relevance, and whether it is important for cytokine activity (By similarity).
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[https://www.uniprot.org/uniprot/MIF_RAT MIF_RAT] Pro-inflammatory cytokine. Involved in the innate immune response to bacterial pathogens. The expression of MIF at sites of inflammation suggests a role as mediator in regulating the function of macrophages in host defense. Counteracts the anti-inflammatory activity of glucocorticoids. Has phenylpyruvate tautomerase and dopachrome tautomerase activity (in vitro), but the physiological substrate is not known. It is not clear whether the tautomerase activity has any physiological relevance, and whether it is important for cytokine activity (By similarity).
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Buffalo rat]]
 
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Nakagawa, A]]
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[[Category: Rattus norvegicus]]
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[[Category: Sugimoto, H]]
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[[Category: Nakagawa A]]
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[[Category: Suzuki, M]]
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[[Category: Sugimoto H]]
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[[Category: Tanaka, I]]
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[[Category: Suzuki M]]
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[[Category: Cytokine]]
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[[Category: Tanaka I]]
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[[Category: Inflammatory response]]
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[[Category: Macrophage]]
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Current revision

MACROPHAGE MIGRATION INHIBITORY FACTOR

PDB ID 1fim

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