1ilz

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<StructureSection load='1ilz' size='340' side='right'caption='[[1ilz]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
<StructureSection load='1ilz' size='340' side='right'caption='[[1ilz]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1ilz]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ILZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ILZ FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1ilz]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ILZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ILZ FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BOG:B-OCTYLGLUCOSIDE'>BOG</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BOG:B-OCTYLGLUCOSIDE'>BOG</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1qd5|1qd5]], [[1qd6|1qd6]], [[1fw2|1fw2]], [[1ild|1ild]], [[1fw3|1fw3]], [[1im0|1im0]]</div></td></tr>
 
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">pldA ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>
 
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Phospholipase_A(1) Phospholipase A(1)], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.32 3.1.1.32] </span></td></tr>
 
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ilz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ilz OCA], [https://pdbe.org/1ilz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ilz RCSB], [https://www.ebi.ac.uk/pdbsum/1ilz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ilz ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ilz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ilz OCA], [https://pdbe.org/1ilz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ilz RCSB], [https://www.ebi.ac.uk/pdbsum/1ilz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ilz ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/PA1_ECOLI PA1_ECOLI]] Has broad substrate specificity including hydrolysis of phosphatidylcholine with phospholipase A2 (EC 3.1.1.4) and phospholipase A1 (EC 3.1.1.32) activities. Strong expression leads to outer membrane breakdown and cell death; is dormant in normal growing cells. Required for efficient secretion of bacteriocins.
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[https://www.uniprot.org/uniprot/PA1_ECOLI PA1_ECOLI] Has broad substrate specificity including hydrolysis of phosphatidylcholine with phospholipase A2 (EC 3.1.1.4) and phospholipase A1 (EC 3.1.1.32) activities. Strong expression leads to outer membrane breakdown and cell death; is dormant in normal growing cells. Required for efficient secretion of bacteriocins.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Bacillus coli migula 1895]]
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[[Category: Escherichia coli]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Dekker, N]]
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[[Category: Dekker N]]
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[[Category: Dijkstra, B W]]
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[[Category: Dijkstra BW]]
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[[Category: Eerde, J H.Van]]
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[[Category: Egmond MR]]
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[[Category: Egmond, M R]]
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[[Category: Kalk KH]]
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[[Category: Kalk, K H]]
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[[Category: Kingma RL]]
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[[Category: Kingma, R L]]
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[[Category: Snijder HJ]]
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[[Category: Snijder, H J]]
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[[Category: Van Eerde JH]]
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[[Category: Anti-parallel beta barrel]]
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[[Category: Asn ala mutation]]
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[[Category: Catalytic triad]]
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[[Category: Hydrolase]]
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[[Category: Membrane phospholipase]]
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[[Category: Membrane protein]]
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[[Category: Serine hydrolase]]
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Revision as of 09:40, 21 December 2022

OUTER MEMBRANE PHOSPHOLIPASE A FROM ESCHERICHIA COLI N156A ACTIVE SITE MUTANT pH 6.1

PDB ID 1ilz

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