1jeo
From Proteopedia
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'''Crystal Structure of the Hypothetical Protein MJ1247 from Methanococcus jannaschii at 2.0 A Resolution Infers a Molecular Function of 3-Hexulose-6-Phosphate isomerase.''' | '''Crystal Structure of the Hypothetical Protein MJ1247 from Methanococcus jannaschii at 2.0 A Resolution Infers a Molecular Function of 3-Hexulose-6-Phosphate isomerase.''' | ||
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[[Category: Yokota, H.]] | [[Category: Yokota, H.]] | ||
[[Category: 3-hexulose-6-phosphate isomerase]] | [[Category: 3-hexulose-6-phosphate isomerase]] | ||
| - | [[Category: | + | [[Category: Berkeley structural genomics center]] |
| - | [[Category: | + | [[Category: Bsgc structure funded by nih]] |
| - | [[Category: | + | [[Category: Phi]] |
| - | [[Category: | + | [[Category: Phosphosugar]] |
| - | [[Category: | + | [[Category: Protein structure initiative]] |
| - | [[Category: | + | [[Category: Psi]] |
| - | [[Category: | + | [[Category: Rump pathway]] |
| - | [[Category: | + | [[Category: Structural genomic]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 21:07:56 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 18:07, 2 May 2008
Crystal Structure of the Hypothetical Protein MJ1247 from Methanococcus jannaschii at 2.0 A Resolution Infers a Molecular Function of 3-Hexulose-6-Phosphate isomerase.
Overview
The crystal structure of the hypothetical protein MJ1247 from Methanococccus jannaschii at 2 A resolution, a detailed sequence analysis, and biochemical assays infer its molecular function to be 3-hexulose-6-phosphate isomerase (PHI). In the dissimilatory ribulose monophosphate (RuMP) cycle, ribulose-5-phosphate is coupled to formaldehyde by the 3-hexulose-6-phosphate synthase (HPS), yielding hexulose-6-phosphate, which is then isomerized to fructose-6-phosphate by the enzyme 3-hexulose-6-phosphate isomerase. MJ1247 is an alpha/beta structure consisting of a five-stranded parallel beta sheet flanked on both sides by alpha helices, forming a three-layered alpha-beta-alpha sandwich. The fold represents the nucleotide binding motif of a flavodoxin type. MJ1247 is a tetramer in the crystal and in solution and each monomer has a folding similar to the isomerase domain of glucosamine-6-phosphate synthase (GlmS).
About this Structure
1JEO is a Single protein structure of sequence from Methanocaldococcus jannaschii. Full crystallographic information is available from OCA.
Reference
Crystal structure of MJ1247 protein from M. jannaschii at 2.0 A resolution infers a molecular function of 3-hexulose-6-phosphate isomerase., Martinez-Cruz LA, Dreyer MK, Boisvert DC, Yokota H, Martinez-Chantar ML, Kim R, Kim SH, Structure. 2002 Feb;10(2):195-204. PMID:11839305 Page seeded by OCA on Fri May 2 21:07:56 2008
Categories: Methanocaldococcus jannaschii | Single protein | BSGC, Berkeley Structural Genomics Center. | Boisvert, D C. | Dreyer, M K. | Kim, R. | Kim, S H. | Martinez-Chantar, M L. | Martinez-Cruz, L A. | Yokota, H. | 3-hexulose-6-phosphate isomerase | Berkeley structural genomics center | Bsgc structure funded by nih | Phi | Phosphosugar | Protein structure initiative | Psi | Rump pathway | Structural genomic
