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| | <StructureSection load='6s5w' size='340' side='right'caption='[[6s5w]], [[Resolution|resolution]] 1.07Å' scene=''> | | <StructureSection load='6s5w' size='340' side='right'caption='[[6s5w]], [[Resolution|resolution]] 1.07Å' scene=''> |
| | == Structural highlights == | | == Structural highlights == |
| - | <table><tr><td colspan='2'>[[6s5w]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_acidophilus"_moro_1900 "bacillus acidophilus" moro 1900]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6S5W OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6S5W FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[6s5w]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Lactobacillus_acidophilus Lactobacillus acidophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6S5W OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6S5W FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> |
| - | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">LBA1633 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1579 "Bacillus acidophilus" Moro 1900])</td></tr>
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6s5w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6s5w OCA], [https://pdbe.org/6s5w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6s5w RCSB], [https://www.ebi.ac.uk/pdbsum/6s5w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6s5w ProSAT]</span></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6s5w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6s5w OCA], [http://pdbe.org/6s5w PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6s5w RCSB], [http://www.ebi.ac.uk/pdbsum/6s5w PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6s5w ProSAT]</span></td></tr> | + | |
| | </table> | | </table> |
| | + | == Function == |
| | + | [https://www.uniprot.org/uniprot/Q5FIM8_LACAC Q5FIM8_LACAC] |
| | <div style="background-color:#fffaf0;"> | | <div style="background-color:#fffaf0;"> |
| | == Publication Abstract from PubMed == | | == Publication Abstract from PubMed == |
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| | __TOC__ | | __TOC__ |
| | </StructureSection> | | </StructureSection> |
| - | [[Category: Bacillus acidophilus moro 1900]] | + | [[Category: Lactobacillus acidophilus]] |
| | [[Category: Large Structures]] | | [[Category: Large Structures]] |
| - | [[Category: Bateman, A]] | + | [[Category: Bateman A]] |
| - | [[Category: Cooper, R E.M]] | + | [[Category: Cooper REM]] |
| - | [[Category: Griffiths, S C]] | + | [[Category: Griffiths SC]] |
| - | [[Category: Potts, J R]] | + | [[Category: Potts JR]] |
| - | [[Category: Whelan, F]] | + | [[Category: Whelan F]] |
| - | [[Category: Whittingham, J L]] | + | [[Category: Whittingham JL]] |
| - | [[Category: Bacterial cell surface]]
| + | |
| - | [[Category: Domain atrophy]]
| + | |
| - | [[Category: Immunoglobulin fold]]
| + | |
| - | [[Category: Profile-hmm]]
| + | |
| - | [[Category: Rib domain]]
| + | |
| - | [[Category: Structural protein]]
| + | |
| Structural highlights
Function
Q5FIM8_LACAC
Publication Abstract from PubMed
Streptococcus groups A and B cause serious infections, including early onset sepsis and meningitis in newborns. Rib domain-containing surface proteins are found associated with invasive strains and elicit protective immunity in animal models. Yet, despite their apparent importance in infection, the structure of the Rib domain was previously unknown. Structures of single Rib domains of differing length reveal a rare case of domain atrophy through deletion of 2 core antiparallel strands, resulting in the loss of an entire sheet of the beta-sandwich from an immunoglobulin-like fold. Previously, observed variation in the number of Rib domains within these bacterial cell wall-attached proteins has been suggested as a mechanism of immune evasion. Here, the structure of tandem domains, combined with molecular dynamics simulations and small angle X-ray scattering, suggests that variability in Rib domain number would result in differential projection of an N-terminal host-colonization domain from the bacterial surface. The identification of 2 further structures where the typical B-D-E immunoglobulin beta-sheet is replaced with an alpha-helix further confirms the extensive structural malleability of the Rib domain.
Defining the remarkable structural malleability of a bacterial surface protein Rib domain implicated in infection.,Whelan F, Lafita A, Griffiths SC, Cooper REM, Whittingham JL, Turkenburg JP, Manfield IW, St John AN, Paci E, Bateman A, Potts JR Proc Natl Acad Sci U S A. 2019 Dec 9. pii: 1911776116. doi:, 10.1073/pnas.1911776116. PMID:31818940[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
References
- ↑ Whelan F, Lafita A, Griffiths SC, Cooper REM, Whittingham JL, Turkenburg JP, Manfield IW, St John AN, Paci E, Bateman A, Potts JR. Defining the remarkable structural malleability of a bacterial surface protein Rib domain implicated in infection. Proc Natl Acad Sci U S A. 2019 Dec 9. pii: 1911776116. doi:, 10.1073/pnas.1911776116. PMID:31818940 doi:http://dx.doi.org/10.1073/pnas.1911776116
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