1hyn

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Revision as of 15:17, 12 November 2007

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spinqualitylabelsall models 1hyn, resolution 2.6Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

CRYSTAL STRUCTURE OF THE CYTOPLASMIC DOMAIN OF HUMAN ERYTHROCYTE BAND-3 PROTEIN

Contents 1 Overview 2 Disease 3 About this Structure 4 Reference

Overview

The red blood cell membrane (RBCM) is a primary model for animal cell, plasma membranes. One of its major organizing centers is the cytoplasmic, domain of band 3 (cdb3), which links multiple proteins to the membrane., Included among its peripheral protein ligands are ankyrin (the major, bridge to the spectrin-actin skeleton), protein 4. 1, protein 4.2, aldolase, glyceraldehyde-3-phosphate dehydrogenase, phosphofructokinase, deoxyhemoglobin, p72syk protein tyrosine kinase, and hemichromes. The, crystal structure of cdb3 is reported at 0.26 nm (2.6 A) resolution. A, tight symmetric dimer is formed by cdb3; it is stabilized by interlocked, dimerization arms contributed by both monomers. Each subunit also includes, a larger peripheral protein binding domain with an alpha(+) beta-fold. The, binding sites of several peripheral proteins are localized in the, structure, and the nature of the major conformational change that, regulates membrane-skeletal interactions is evaluated. An improved, structural definition of the protein network at the inner surface of the, RBCM is now possible.

Disease

Known diseases associated with this structure: Acanthocytosis, one form OMIM:[109270], Blood group, Diego OMIM:[109270], Blood group, Waldner OMIM:[109270], Blood group, Wright OMIM:[109270], Diabetes insipidus, nephrogenic OMIM:[300538], Elliptocytosis, Malaysian-Melanesian type OMIM:[109270], Hemolytic anemia due to band 3 defect defect OMIM:[109270], Nephrogenic syndrome of inappropriate antidiuresis OMIM:[300538], OMIM:[[1]]109270, Renal tubular acidosis, distal, 179800 OMIM:[109270], Spherocytosis, hereditary OMIM:[109270]

About this Structure

1HYN is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystallographic structure and functional interpretation of the cytoplasmic domain of erythrocyte membrane band 3., Zhang D, Kiyatkin A, Bolin JT, Low PS, Blood. 2000 Nov 1;96(9):2925-33. PMID:11049968

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