1jfd

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
[[Image:1jfd.jpg|left|200px]]
[[Image:1jfd.jpg|left|200px]]
-
{{Structure
+
<!--
-
|PDB= 1jfd |SIZE=350|CAPTION= <scene name='initialview01'>1jfd</scene>, resolution 2.2&Aring;
+
The line below this paragraph, containing "STRUCTURE_1jfd", creates the "Structure Box" on the page.
-
|SITE=
+
You may change the PDB parameter (which sets the PDB file loaded into the applet)
-
|LIGAND= <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>
+
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-
|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Inorganic_diphosphatase Inorganic diphosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.1.1 3.6.1.1] </span>
+
or leave the SCENE parameter empty for the default display.
-
|GENE=
+
-->
-
|DOMAIN=
+
{{STRUCTURE_1jfd| PDB=1jfd | SCENE= }}
-
|RELATEDENTRY=
+
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jfd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jfd OCA], [http://www.ebi.ac.uk/pdbsum/1jfd PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1jfd RCSB]</span>
+
-
}}
+
'''STRUCTURE OF INORGANIC PYROPHOSPHATASE'''
'''STRUCTURE OF INORGANIC PYROPHOSPHATASE'''
Line 30: Line 27:
[[Category: Huber, R.]]
[[Category: Huber, R.]]
[[Category: Oganesyan, V.]]
[[Category: Oganesyan, V.]]
-
[[Category: acid anhydride hydrolase]]
+
[[Category: Acid anhydride hydrolase]]
-
[[Category: hydrolase]]
+
[[Category: Hydrolase]]
-
 
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 21:09:32 2008''
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:32:52 2008''
+

Revision as of 18:09, 2 May 2008

Image:1jfd.jpg

Template:STRUCTURE 1jfd

STRUCTURE OF INORGANIC PYROPHOSPHATASE


Overview

The three-dimensional structure of inorganic pyrophosphatase from Escherichia coli complexed with sulfate was determined at 2.2 A resolution using Patterson's search technique and refmed to an R-factor of 19.2%. Sulfate may be regarded as a structural analog of phosphate, the product of the enzyme reaction, and as a structural analog of methyl phosphate, the irreversible inhibitor. Sulfate binds to the pyrophosphatase active site cavity as does phosphate and this diminishes molecular symmetry, converting the homohexamer structure form (alpha3)2 into alpha3'alpha3". The asymmetry of the molecule is manifested in displacements of protein functional groups and some parts of the polypeptide chain and reflects the interaction of subunits and their cooperation. The significance of re-arrangements for pyrophosphatase function is discussed.

About this Structure

1JFD is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Crystal structure of Escherichia coli inorganic pyrophosphatase complexed with SO4(2-). Ligand-induced molecular asymmetry., Avaeva S, Kurilova S, Nazarova T, Rodina E, Vorobyeva N, Sklyankina V, Grigorjeva O, Harutyunyan E, Oganessyan V, Wilson K, Dauter Z, Huber R, Mather T, FEBS Lett. 1997 Jun 30;410(2-3):502-8. PMID:9237692 Page seeded by OCA on Fri May 2 21:09:32 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1jfd"
Personal tools