1jfg

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[[Image:1jfg.jpg|left|200px]]
[[Image:1jfg.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 1jfg |SIZE=350|CAPTION= <scene name='initialview01'>1jfg</scene>, resolution 2.5&Aring;
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The line below this paragraph, containing "STRUCTURE_1jfg", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=POP:PYROPHOSPHATE+2-'>POP</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Trichodiene_synthase Trichodiene synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.3.6 4.2.3.6] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE= TRI5 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5514 Fusarium sporotrichioides])
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-->
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|DOMAIN=
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{{STRUCTURE_1jfg| PDB=1jfg | SCENE= }}
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|RELATEDENTRY=[[1jfa|1JFA]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jfg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jfg OCA], [http://www.ebi.ac.uk/pdbsum/1jfg PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1jfg RCSB]</span>
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}}
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'''TRICHODIENE SYNTHASE FROM FUSARIUM SPOROTRICHIOIDES COMPLEXED WITH DIPHOSPHATE'''
'''TRICHODIENE SYNTHASE FROM FUSARIUM SPOROTRICHIOIDES COMPLEXED WITH DIPHOSPHATE'''
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[[Category: Christianson, D W.]]
[[Category: Christianson, D W.]]
[[Category: Rynkiewicz, M J.]]
[[Category: Rynkiewicz, M J.]]
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[[Category: terpenoid synthase fold]]
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[[Category: Terpenoid synthase fold]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 21:09:36 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:32:53 2008''
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Revision as of 18:09, 2 May 2008

Image:1jfg.jpg

Template:STRUCTURE 1jfg

TRICHODIENE SYNTHASE FROM FUSARIUM SPOROTRICHIOIDES COMPLEXED WITH DIPHOSPHATE


Overview

The x-ray crystal structure of recombinant trichodiene synthase from Fusarium sporotrichioides has been determined to 2.5-A resolution, both unliganded and complexed with inorganic pyrophosphate. This reaction product coordinates to three Mg(2+) ions near the mouth of the active site cleft. A comparison of the liganded and unliganded structures reveals a ligand-induced conformational change that closes the mouth of the active site cleft. Binding of the substrate farnesyl diphosphate similarly may trigger this conformational change, which would facilitate catalysis by protecting reactive carbocationic intermediates in the cyclization cascade. Trichodiene synthase also shares significant structural similarity with other sesquiterpene synthases despite a lack of significant sequence identity. This similarity indicates divergence from a common ancestor early in the evolution of terpene biosynthesis.

About this Structure

1JFG is a Single protein structure of sequence from Fusarium sporotrichioides. Full crystallographic information is available from OCA.

Reference

Structure of trichodiene synthase from Fusarium sporotrichioides provides mechanistic inferences on the terpene cyclization cascade., Rynkiewicz MJ, Cane DE, Christianson DW, Proc Natl Acad Sci U S A. 2001 Nov 20;98(24):13543-8. Epub 2001 Nov 6. PMID:11698643 Page seeded by OCA on Fri May 2 21:09:36 2008

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