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4lv5

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==Murine IRGa6 bound to Toxoplasma ROP5B, a pseudokinase GDI==
==Murine IRGa6 bound to Toxoplasma ROP5B, a pseudokinase GDI==
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<StructureSection load='4lv5' size='340' side='right' caption='[[4lv5]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
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<StructureSection load='4lv5' size='340' side='right'caption='[[4lv5]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4lv5]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice] and [http://en.wikipedia.org/wiki/Toxgo Toxgo]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LV5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4LV5 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4lv5]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [https://en.wikipedia.org/wiki/Toxoplasma_gondii Toxoplasma gondii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LV5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4LV5 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4lv8|4lv8]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4lv5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4lv5 OCA], [https://pdbe.org/4lv5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4lv5 RCSB], [https://www.ebi.ac.uk/pdbsum/4lv5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4lv5 ProSAT]</span></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ROP5, ROP5B ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5811 TOXGO]), Iigp1, Irga6 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4lv5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4lv5 OCA], [http://pdbe.org/4lv5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4lv5 RCSB], [http://www.ebi.ac.uk/pdbsum/4lv5 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4lv5 ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/IIGP1_MOUSE IIGP1_MOUSE]] GTPase with low activity. Has higher affinity for GDP than for GTP. Plays a role in resistance to intracellular pathogens. Required for disruption of the parasitophorous vacuole formed following T.gondii infection and subsequent killing of the parasite. Mediates resistance to C.trachomatis infection by targeting bacterial inclusions to autophagosomes for subsequent lysosomal destruction.<ref>PMID:11907101</ref> <ref>PMID:16304607</ref> <ref>PMID:19242543</ref> <ref>PMID:12732635</ref>
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[https://www.uniprot.org/uniprot/F2YGR7_TOXGO F2YGR7_TOXGO]
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== References ==
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<references/>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Lk3 transgenic mice]]
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[[Category: Large Structures]]
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[[Category: Toxgo]]
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[[Category: Mus musculus]]
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[[Category: Boothroyd, J C]]
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[[Category: Toxoplasma gondii]]
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[[Category: Reese, M L]]
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[[Category: Boothroyd JC]]
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[[Category: Guanine dissociation inhibitor]]
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[[Category: Reese ML]]
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[[Category: Immune related gtpase]]
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[[Category: Parasite effector]]
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[[Category: Transferase-hydrolase complex]]
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Revision as of 10:33, 21 December 2022

Murine IRGa6 bound to Toxoplasma ROP5B, a pseudokinase GDI

PDB ID 4lv5

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