1jfm
From Proteopedia
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'''CRYSTAL STRUCTURE OF MURINE NK CELL LIGAND RAE-1 BETA''' | '''CRYSTAL STRUCTURE OF MURINE NK CELL LIGAND RAE-1 BETA''' | ||
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[[Category: Li, P.]] | [[Category: Li, P.]] | ||
[[Category: Strong, R K.]] | [[Category: Strong, R K.]] | ||
| - | [[Category: | + | [[Category: Mhc-i platform]] |
| - | [[Category: | + | [[Category: Murine nk cell ligand]] |
| - | [[Category: | + | [[Category: Nkg2d]] |
| - | [[Category: | + | [[Category: Rae-1 beta]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 21:09:59 2008'' | |
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Revision as of 18:10, 2 May 2008
CRYSTAL STRUCTURE OF MURINE NK CELL LIGAND RAE-1 BETA
Overview
Induced by retinoic acid and implicated in playing a role in development, rodent RAE-1 proteins are ligands for the activating immunoreceptor NKG2D, widely expressed on natural killer cells, T cells, and macrophages. RAE-1 proteins (alpha, beta, gamma, and delta) are distant major histocompatibility complex (MHC) class I homologs, comprising isolated alpha1alpha2 platform domains. The crystal structure of RAE-1beta was distorted from other MHC homologs and displayed noncanonical disulfide bonds. The loss of any remnant of a peptide binding groove was facilitated by the close approach of the groove-defining helices through a hydrophobic, leucine-rich interface. The RAE-1beta-murine NKG2D complex structure resembled the human NKG2D-MICA receptor-ligand complex and further demonstrated the promiscuity of the NKG2D ligand binding site.
About this Structure
1JFM is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.
Reference
Crystal structures of RAE-1beta and its complex with the activating immunoreceptor NKG2D., Li P, McDermott G, Strong RK, Immunity. 2002 Jan;16(1):77-86. PMID:11825567 Page seeded by OCA on Fri May 2 21:09:59 2008
