4lwu

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<StructureSection load='4lwu' size='340' side='right'caption='[[4lwu]], [[Resolution|resolution]] 1.14&Aring;' scene=''>
<StructureSection load='4lwu' size='340' side='right'caption='[[4lwu]], [[Resolution|resolution]] 1.14&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4lwu]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/African_clawed_frog African clawed frog]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LWU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4LWU FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4lwu]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Xenopus_laevis Xenopus laevis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LWU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4LWU FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=20U:(2S,3R,4S,5R)-N-(4-CARBAMOYLPHENYL)-6-CHLORO-4-(3-CHLORO-2-FLUOROPHENYL)-2-(2,2-DIMETHYLPROPYL)-2-OXO-1,2-DIHYDROSPIRO[INDOLE-3,3-PYRROLIDINE]-5-CARBOXAMIDE'>20U</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=20U:(2S,3R,4S,5R)-N-(4-CARBAMOYLPHENYL)-6-CHLORO-4-(3-CHLORO-2-FLUOROPHENYL)-2-(2,2-DIMETHYLPROPYL)-2-OXO-1,2-DIHYDROSPIRO[INDOLE-3,3-PYRROLIDINE]-5-CARBOXAMIDE'>20U</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4lwt|4lwt]], [[4lwv|4lwv]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4lwu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4lwu OCA], [https://pdbe.org/4lwu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4lwu RCSB], [https://www.ebi.ac.uk/pdbsum/4lwu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4lwu ProSAT]</span></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">mdm2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=8355 African clawed frog])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4lwu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4lwu OCA], [http://pdbe.org/4lwu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4lwu RCSB], [http://www.ebi.ac.uk/pdbsum/4lwu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4lwu ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/MDM2_XENLA MDM2_XENLA]] E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degration by the proteasome (By similarity).
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[https://www.uniprot.org/uniprot/MDM2_XENLA MDM2_XENLA] E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degration by the proteasome (By similarity).
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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==See Also==
==See Also==
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*[[MDM2|MDM2]]
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*[[MDM2 3D structures|MDM2 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: African clawed frog]]
 
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Graves, B J]]
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[[Category: Xenopus laevis]]
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[[Category: Janson, C A]]
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[[Category: Graves BJ]]
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[[Category: Lukacs, C]]
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[[Category: Janson CA]]
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[[Category: E3 ubiquitin ligase]]
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[[Category: Lukacs C]]
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[[Category: Ligase-ligase inhibitor complex]]
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[[Category: Mdm2]]
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[[Category: Nucleus]]
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[[Category: P53]]
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[[Category: Spiroindolinone]]
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Revision as of 10:38, 21 December 2022

The 1.14A Crystal Structure of Humanized Xenopus MDM2 with RO5499252

PDB ID 4lwu

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