1jfp
From Proteopedia
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'''Structure of bovine rhodopsin (dark adapted)''' | '''Structure of bovine rhodopsin (dark adapted)''' | ||
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[[Category: Choi, G.]] | [[Category: Choi, G.]] | ||
[[Category: Yeagle, P L.]] | [[Category: Yeagle, P L.]] | ||
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Revision as of 18:10, 2 May 2008
Structure of bovine rhodopsin (dark adapted)
Overview
Activation of G-protein coupled receptors (GPCR) is not yet understood. A recent structure showed most of rhodopsin in the ground (not activated) state of the GPCR, but the cytoplasmic face, which couples to the G protein in signal transduction, was not well-defined. We have determined an experimental three-dimensional structure for rhodopsin in the unactivated state, which shows good agreement with the crystal structure in the transmembrane domain. This new structure defines the cytoplasmic face of rhodopsin. The G-protein binding site can be mapped. The same experimental approach yields a preliminary structure of the cytoplasmic face in the activated (metarhodopsin II) receptor. Differences between the two structures suggest how the receptor is activated to couple with transducin.
About this Structure
1JFP is a Single protein structure of sequence from Bos taurus. Full crystallographic information is available from OCA.
Reference
Studies on the structure of the G-protein-coupled receptor rhodopsin including the putative G-protein binding site in unactivated and activated forms., Yeagle PL, Choi G, Albert AD, Biochemistry. 2001 Oct 2;40(39):11932-7. PMID:11570894 Page seeded by OCA on Fri May 2 21:10:13 2008
