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4m18

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==Crystal Structure of Surfactant Protein-D D325A/R343V mutant in complex with trimannose (Man-a1,2Man-a1,2Man)==
==Crystal Structure of Surfactant Protein-D D325A/R343V mutant in complex with trimannose (Man-a1,2Man-a1,2Man)==
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<StructureSection load='4m18' size='340' side='right' caption='[[4m18]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
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<StructureSection load='4m18' size='340' side='right'caption='[[4m18]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4m18]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4M18 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4M18 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4m18]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4M18 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4M18 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=PRD_900111:2alpha-alpha-mannobiose'>PRD_900111</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4m17|4m17]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4m18 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4m18 OCA], [https://pdbe.org/4m18 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4m18 RCSB], [https://www.ebi.ac.uk/pdbsum/4m18 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4m18 ProSAT]</span></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">COLEC7, PSPD, SFTP4, SFTPD ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4m18 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4m18 OCA], [http://pdbe.org/4m18 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4m18 RCSB], [http://www.ebi.ac.uk/pdbsum/4m18 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4m18 ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/SFTPD_HUMAN SFTPD_HUMAN]] Contributes to the lung's defense against inhaled microorganisms. May participate in the extracellular reorganization or turnover of pulmonary surfactant. Binds strongly maltose residues and to a lesser extent other alpha-glucosyl moieties.
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[https://www.uniprot.org/uniprot/SFTPD_HUMAN SFTPD_HUMAN] Contributes to the lung's defense against inhaled microorganisms. May participate in the extracellular reorganization or turnover of pulmonary surfactant. Binds strongly maltose residues and to a lesser extent other alpha-glucosyl moieties.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
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[[Category: Allen, K]]
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[[Category: Large Structures]]
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[[Category: Cafarella, T R]]
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[[Category: Allen K]]
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[[Category: Calin, O]]
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[[Category: Cafarella TR]]
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[[Category: Crouch, E C]]
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[[Category: Calin O]]
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[[Category: Goh, B C]]
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[[Category: Crouch EC]]
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[[Category: Hartshorn, K L]]
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[[Category: Goh BC]]
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[[Category: Rynkiewicz, M J]]
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[[Category: Hartshorn KL]]
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[[Category: Schulten, K]]
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[[Category: Rynkiewicz MJ]]
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[[Category: Seaton, B A]]
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[[Category: Schulten K]]
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[[Category: Seeberger, P H]]
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[[Category: Seaton BA]]
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[[Category: White, M R]]
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[[Category: Seeberger PH]]
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[[Category: Carbohydrate recognition domain]]
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[[Category: White MR]]
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[[Category: Lectin]]
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[[Category: Sugar binding protein]]
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[[Category: Surfactant protein]]
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Revision as of 10:46, 21 December 2022

Crystal Structure of Surfactant Protein-D D325A/R343V mutant in complex with trimannose (Man-a1,2Man-a1,2Man)

PDB ID 4m18

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